if the current dose is still working, going up is spending headroom you might want later
holding is not failing. most people here who lasted two years held at least one dose for months
#dosing-titration 2026-04-27
Monday23 messages6 participantstimes are UTC
Highlights from this day
- taper_or_not — if the current dose is still working, going up is spending headroom you might want later holding is not failing. most people here who lasted two years held at least… 18:04
- gradient_greg — the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess 18:33
- tokyo_taper — came down from a treatment dose to maintenance over about three months and it was uneventful nobody here can tell you what dose to be on and the ones who try get… 19:57
- tokyo_taper — the people who do best here are almost always the ones going slowest 20:37
- tokyo_taper — a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored 21:23
held for months
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the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
unrelated but update from 5 months ago: held at the same dose the whole time and still losing slowly
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
steady state is 5 weeks
right so is it normal for appetite to come back at the end of the week
[edited]the honest answer is that most of us are running protocols nobody has ever studied
ok so my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
split dosing has no trial behind it. people here do it and report on it, thats all
i went up too fast and im paying for it, do i drop back or ride it out
i went from 2 to 1.7 and honestly could not tell the difference in appetite
came down from a treatment dose to maintenance over about three months and it was uneventful
nobody here can tell you what dose to be on and the ones who try get corrected
U-100 syringe: 1 unit = 0.01 ml
10u = 0.10 ml
25u = 0.25 ml
50u = 0.50 ml
100u = 1.00 ml
mg drawn = ml drawn x mg/mlholding is not failing. most people here who lasted two years held at least one dose for months
appetite returning at the end of the week is extremely common and is not the dose failing
my dose day has drifted 9 days later over 18 months, does it matter
unrelated but what does the room think about jumping a rung to catch up
i would hold
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the people who do best here are almost always the ones going slowest
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quick one you do not have to escalate at all. that is a real option that gets forgotten
the trials escalated on a fixed schedule because a trial has to. you are not a trial
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
end of week thing