not advice
#dosing-titration 2026-04-25
Saturday49 messages10 participantstimes are UTC
Highlights from this day
- food_noise_off — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice 19:45
- holly_holds — appetite returning at the end of the week is extremely common and is not the dose failing, someone check my working split dosing has no trial behind it. people here… 20:02
- see_a_clinician — my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step appetite returning at the end of the week is extremely common and is… 20:59
- eat_more_please — i escalate on symptoms. if the current dose is still doing something i stay on it 21:05
- see_a_clinician — is week 8 too early to be thinking about the next step 23:20
how long did you hold at 0.25 before you moved up
stepping back down on purpose is a completely reasonable move and this channel should say so more often
i went up too fast and im paying for it, do i drop back or ride it out
Inter-lab diff for lot F-1330: 98.1% vs 97.4%. Within expected range.
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is there a trial anywhere that studied twice weekly, or is it all anecdote
the honest answer is that most of us are running protocols nobody has ever studied
[edited]my titration ladder took 22 months to climb and i would do it slower again
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
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if the current dose is still working, going up is spending headroom you might want later
thats noise
held for months
update from 20 months ago: held at the same dose the whole time and still losing slowly
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
while im here if i hold at 0.5 indefinitely am i losing anything
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holding is not failing. most people here who lasted two years held at least one dose for months
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my dose day has drifted 3 days later over 25 months, does it matter
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat, i have it written down somewhere
if it "stopped working after four days" that is almost never pharmacokinetics, thats one data point
came down, no regrets
genuine question the people who do best here are almost always the ones going slowest
genuine question if you are asking whether to go up, the fact you are asking usually means not yet
coming back to this is there any actual reason to escalate every 4 weeks other than the trial did it
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i have been at 1.7 for 14 months and honestly i have stopped wanting to move
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
steady state is 5 weeks
coming back to this you do not have to escalate at all. that is a real option that gets forgotten
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after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)came down from a treatment dose to maintenance over about three months and it was uneventful
appetite returning at the end of the week is extremely common and is not the dose failing, someone check my working
split dosing has no trial behind it. people here do it and report on it, thats all
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update on the earlier thing anyone here split their weekly into two and would they do it again
split dosing has no trial behind it. people here do it and report on it, thats all, n of 1 obviously
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
small steps are better than big ones and the only reason people take big ones is impatience, ymmv
unrelated but coming down from 0.25 to 1, how bad is the appetite rebound
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coming back to this i drifted from sunday to wednesday over a year and only noticed when i checked the log
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
two weeks is nothing
[edited]i would hold
the trials escalated on a fixed schedule because a trial has to. you are not a trial, thats one data point
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the ladder in the trials is a starting point, not a schedule you owe anyone
whats a sensible maintenance dose after a year at treatment dose
right so i hold for two months minimum before i decide a dose has stopped doing anything
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
appetite returning at the end of the week is extremely common and is not the dose failing
do you count from injection day or from when you actually felt it
thats anecdote
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i escalate on symptoms. if the current dose is still doing something i stay on it
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is week 8 too early to be thinking about the next step
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