how do you tell a plateau from just being at your set point
#dosing-titration 2026-04-22
Wednesday38 messages10 participantstimes are UTC
Highlights from this day
thats normal
if the current dose is still working, going up is spending headroom you might want later
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
with a roughly seven day half-life you are near steady state after about five weeks at a dose
i have been at 5 for 7 months and honestly i have stopped wanting to move
update question: did anyone who held for 17 months regret it
do you tell your prescriber you held or do you just hold
🤝3📉1
came down from a treatment dose to maintenance over about three months and it was uneventful
small steps are better than big ones and the only reason people take big ones is impatience
holding is not failing. most people here who lasted two years held at least one dose for months
❤️1⚠️2
stepping back down on purpose is a completely reasonable move and this channel should say so more often, happy to be corrected
slightly off topic but if it "stopped working after four days" that is almost never pharmacokinetics
Archive lookup: tess_tirz first appears in this channel on 2026-03-19.
my dose day has drifted 7 days later over 18 months, does it matter
[edited]🎉4✅12👀12
n of 1
do you escalate on the calendar or on how you feel
whats the smallest step anyone has managed between doses
how much does the last dose still matter 8 days later
the ladder in the trials is a starting point, not a schedule you owe anyone
for the archive does a missed week reset anything or do you just carry on
if you are asking whether to go up, the fact you are asking usually means not yet
🔥2
is week 13 too early to be thinking about the next step
anyone here split their weekly into two and would they do it again
how do you decide between holding and stepping when both feel wrong
i went from 0.5 to 2.5 and honestly could not tell the difference in appetite
if i took it 2 days late do i shift the schedule or go back to the old day
❤️4🙏12👍12
no trial for that
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
the trials escalated on a fixed schedule because a trial has to. you are not a trial
Recon calculator: 2mg in 0.5ml = 2.5mg/ml.
genuine question appetite returning at the end of the week is extremely common and is not the dose failing
i would hold
my titration ladder took 15 months to climb and i would do it slower again
is there a point where going up stops buying you anything
coming back to this i drifted from sunday to wednesday over a year and only noticed when i checked the log, ymmv
you do not have to escalate at all. that is a real option that gets forgotten
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
😂1👍1🎉5