while im here do you escalate on the calendar or on how you feel
#dosing-titration 2026-04-18
Saturday40 messages10 participantstimes are UTC
Highlights from this day
- endotoxin_ed — split dosing has no trial behind it. people here do it and report on it, thats all 21:51
- VialBot — Digest for the week of 2025-11-19 has been published. 22:40
- ghent_gradient — dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, we shall see 22:42
- pinch_not_stretch — appetite returning at the end of the week is extremely common and is not the dose failing 23:01
two weeks is nothing
unrelated but holding is not failing. most people here who lasted two years held at least one dose for months
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how do you tell a plateau from just being at your set point
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
ok so do you tell your prescriber you held or do you just hold
i went from 2.5 to 2.4 and honestly could not tell the difference in appetite, i think
update from 25 months ago: held at the same dose the whole time and still losing slowly, we shall see
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sorry to jump in is it normal for appetite to come back at the end of the week
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split dosing has no trial behind it. people here do it and report on it, thats all
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my titration ladder took 24 months to climb and i would do it slower again
held for months
is week 32 too early to be thinking about the next step
right so whats the longest anyone has stayed on one dose
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plateau versus set point is not answerable in under six months of data
whats your rule for when a side effect means hold rather than push
sorry to jump in the ladder in the trials is a starting point, not a schedule you owe anyone, anyway
i hold for two months minimum before i decide a dose has stopped doing anything, your mileage will differ
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not advice
the people who do best here are almost always the ones going slowest
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the honest answer is that most of us are running protocols nobody has ever studied
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with a roughly seven day half-life you are near steady state after about five weeks at a dose
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coming down from 10 to 1.7, how bad is the appetite rebound
steady state is 5 weeks
you do not have to escalate at all. that is a real option that gets forgotten
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Digest for the week of 2025-11-19 has been published.
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dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, we shall see
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coming back to this a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
came down from a treatment dose to maintenance over about three months and it was uneventful
the trials escalated on a fixed schedule because a trial has to. you are not a trial
does a missed week reset anything or do you just carry on
*week 33 not week 5
hold
i escalate on symptoms. if the current dose is still doing something i stay on it
coming back to this i have been at 0.5 for 18 months and honestly i have stopped wanting to move
appetite returning at the end of the week is extremely common and is not the dose failing
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i drifted from sunday to wednesday over a year and only noticed when i checked the log
no trial for that
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
pick a day and stick to it