came down, no regrets
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#dosing-titration 2026-04-05
Sunday31 messages7 participantstimes are UTC
Highlights from this day
- careful_claims — right so whats the smallest step anyone has managed between doses 18:51
- escalation_anxiety — the trials escalated on a fixed schedule because a trial has to. you are not a trial 20:18
- careful_claims — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice 20:52
the people who do best here are almost always the ones going slowest
if you are asking whether to go up, the fact you are asking usually means not yet
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
small steps are better than big ones and the only reason people take big ones is impatience
if it "stopped working after four days" that is almost never pharmacokinetics
for the archive is there a trial anywhere that studied twice weekly, or is it all anecdote
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[redacted at member request] · archive policy
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
whats a sensible maintenance dose after a year at treatment dose
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thats noise
held for months
end of week thing
coming back to this if you are going up because the scale stalled for two weeks, wait. two weeks is noise
thats anecdote
right so whats the smallest step anyone has managed between doses
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how do you decide between holding and stepping when both feel wrong
unrelated but i went up too fast and im paying for it, do i drop back or ride it out
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
my titration ladder took 12 months to climb and i would do it slower again
update question: did anyone who held for 26 months regret it
follow up the honest answer is that most of us are running protocols nobody has ever studied
too early imo
coa-d-0718.pdf
1 page · 722 KB · not retained in the public archive
i drifted from sunday to wednesday over a year and only noticed when i checked the log
steady state is 5 weeks
whats the longest anyone has stayed on one dose
the trials escalated on a fixed schedule because a trial has to. you are not a trial
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genuine question plateau versus set point is not answerable in under six months of data
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nobody here can tell you what dose to be on and the ones who try get corrected
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
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split dosing has no trial behind it. people here do it and report on it, thats all
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |