two weeks is nothing
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#dosing-titration 2026-03-29
Sunday53 messages11 participantstimes are UTC
Highlights from this day
- declared_value — plateau versus set point is not answerable in under six months of data, not advice obviously 17:26
- underfill_uma — do you tell your prescriber you held or do you just hold 19:02
- underfill_uma — a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored 19:23
- mg_per_ml — i went up too fast and im paying for it, do i drop back or ride it out 21:32
my dose day has drifted 9 days later over 18 months, does it matter
i hold for two months minimum before i decide a dose has stopped doing anything
appetite returning at the end of the week is extremely common and is not the dose failing
the trials escalated on a fixed schedule because a trial has to. you are not a trial
whats the smallest step anyone has managed between doses
small steps are better than big ones and the only reason people take big ones is impatience
thats anecdote
plateau versus set point is not answerable in under six months of data, not advice obviously
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the people who do best here are almost always the ones going slowest
how much does the last dose still matter 3 days later
whats a sensible maintenance dose after a year at treatment dose
go slower
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
thats noise
my titration ladder took 16 months to climb and i would do it slower again, anyway
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after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
if you are asking whether to go up, the fact you are asking usually means not yet
Archive lookup: relabel_watch first appears in this channel on 2025-07-15.
i would hold
U-100 syringe: 1 unit = 0.01 ml
10u = 0.10 ml
25u = 0.25 ml
50u = 0.50 ml
100u = 1.00 ml
mg drawn = ml drawn x mg/mlis it normal for appetite to come back at the end of the week
update from 24 months ago: held at the same dose the whole time and still losing slowly
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steady state is 5 weeks
is there any actual reason to escalate every 4 weeks other than the trial did it
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i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
pick a day and stick to it
follow up does a missed week reset anything or do you just carry on
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
half life is a week
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
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a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
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thats normal
how do you tell a plateau from just being at your set point
no trial for that
stepping back down on purpose is a completely reasonable move and this channel should say so more often
came down, no regrets
if it "stopped working after four days" that is almost never pharmacokinetics
nobody here can tell you what dose to be on and the ones who try get corrected, take that with a pinch of salt
small steps are better than big ones and the only reason people take big ones is impatience, for what its worth
for the archive do you escalate on the calendar or on how you feel
[edited]end of week thing
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
how do you decide between holding and stepping when both feel wrong
i escalate on symptoms. if the current dose is still doing something i stay on it
hold
whats your rule for when a side effect means hold rather than push
the honest answer is that most of us are running protocols nobody has ever studied, thats one data point
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
i have been at 0.5 for 21 months and honestly i have stopped wanting to move
do you count from injection day or from when you actually felt it
coming down from 2 to 1, how bad is the appetite rebound
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgi went up too fast and im paying for it, do i drop back or ride it out
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgcame down from a treatment dose to maintenance over about three months and it was uneventful
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