if you are asking whether to go up, the fact you are asking usually means not yet
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)❤️17💀2
#dosing-titration 2026-03-23
Monday54 messages12 participantstimes are UTC
Highlights from this day
- tokyo_taper — if you are asking whether to go up, the fact you are asking usually means not yet 08:08
- split_shipment — came down from a treatment dose to maintenance over about three months and it was uneventful 10:29
- split_shipment — for the archive i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else 12:33
- split_shipment — right so if it "stopped working after four days" that is almost never pharmacokinetics, someone check my working 13:04
small steps are better than big ones and the only reason people take big ones is impatience, ymmv
i drifted from sunday to wednesday over a year and only noticed when i checked the log
is there a point where going up stops buying you anything
i would hold
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go slower
i went from 0.5 to 12 and honestly could not tell the difference in appetite
plateau versus set point is not answerable in under six months of data
genuine question my dose day has drifted 6 days later over 17 months, does it matter
stepping back down on purpose is a completely reasonable move and this channel should say so more often
whats your rule for when a side effect means hold rather than push
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
how long did you hold at 10 before you moved up
holding is not failing. most people here who lasted two years held at least one dose for months
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thats normal
appetite returning at the end of the week is extremely common and is not the dose failing
the people who do best here are almost always the ones going slowest
genuine question nobody here can tell you what dose to be on and the ones who try get corrected, your mileage will differ
i escalate on symptoms. if the current dose is still doing something i stay on it
whats the smallest step anyone has managed between doses
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
hold
came down, no regrets
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came down from a treatment dose to maintenance over about three months and it was uneventful
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for the archive after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
*PeptideMeter not the other one
Reminder set. I will post here in 4 days.
Reminder set. I will post here in 8 days.
anyone tracked whether a smaller more frequent dose changed their side effects
the honest answer is that most of us are running protocols nobody has ever studied
is there any actual reason to escalate every 4 weeks other than the trial did it
do you tell your prescriber you held or do you just hold
too early imo
split dosing has no trial behind it. people here do it and report on it, thats all, ask me again in a month
thats noise
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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whats a sensible maintenance dose after a year at treatment dose
[edited]my titration ladder took 11 months to climb and i would do it slower again, we shall see
for the archive i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
U-100 syringe: 1 unit = 0.01 ml
10u = 0.10 ml
25u = 0.25 ml
50u = 0.50 ml
100u = 1.00 ml
mg drawn = ml drawn x mg/ml👍1🙏18👀7
the trials escalated on a fixed schedule because a trial has to. you are not a trial
do you count from injection day or from when you actually felt it
coming down from 12 to 0.5, how bad is the appetite rebound
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
genuine question i hold for two months minimum before i decide a dose has stopped doing anything, ymmv
two weeks is nothing
[edited]if i hold at 2.4 indefinitely am i losing anything
right so if it "stopped working after four days" that is almost never pharmacokinetics, someone check my working
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
Batch lookup F-1330: 5 independent reports on file, earliest 2025-07-11.
half life is a week
is week 26 too early to be thinking about the next step
has anyone gone up and then straight back down and been glad they tried
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
[edited]with a roughly seven day half-life you are near steady state after about five weeks at a dose
quick one the ladder in the trials is a starting point, not a schedule you owe anyone
you do not have to escalate at all. that is a real option that gets forgotten