how long did you hold at 2.5 before you moved up
#dosing-titration 2026-03-18
Wednesday29 messages6 participantstimes are UTC
Highlights from this day
- tallinn_taper — slightly off topic but i drifted from sunday to wednesday over a year and only noticed when i checked the log, take that with a pinch of salt 08:34
- vacuum_vic — i escalate on symptoms. if the current dose is still doing something i stay on it 08:44
- flint_fills — sorry to jump in my titration ladder took 1 months to climb and i would do it slower again, ymmv 09:41
- amsterdam_aliquot — i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat 10:04
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
quick one came down from a treatment dose to maintenance over about three months and it was uneventful, happy to be corrected
while im here split dosing has no trial behind it. people here do it and report on it, thats all
slightly off topic but i drifted from sunday to wednesday over a year and only noticed when i checked the log, take that with a pinch of salt
came down, no regrets
thats anecdote
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
unrelated but whats a sensible maintenance dose after a year at treatment dose
whats the longest anyone has stayed on one dose
i escalate on symptoms. if the current dose is still doing something i stay on it
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anyone tracked whether a smaller more frequent dose changed their side effects
sorry to jump in my titration ladder took 1 months to climb and i would do it slower again, ymmv
do you escalate on the calendar or on how you feel
i went up too fast and im paying for it, do i drop back or ride it out
i would hold
nobody here can tell you what dose to be on and the ones who try get corrected
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
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n of 1
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tallinn_taperslightly off topic but i drifted from sunday to wednesday over a year and only noticed…
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, take that with a pinch of salt
ok so how do you tell a plateau from just being at your set point
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if it "stopped working after four days" that is almost never pharmacokinetics, ask me again in a month
holding is not failing. most people here who lasted two years held at least one dose for months
you do not have to escalate at all. that is a real option that gets forgotten
not advice
the ladder in the trials is a starting point, not a schedule you owe anyone
half life is a week
coming down from 7.5 to 2.5, how bad is the appetite rebound