the people who do best here are almost always the ones going slowest, for what its worth
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#dosing-titration 2026-03-12
Thursday40 messages10 participantstimes are UTC
Highlights from this day
- kev_measures — the people who do best here are almost always the ones going slowest, for what its worth 13:18
- kev_measures — split dosing has no trial behind it. people here do it and report on it, thats all 13:31
- typosquat_tay — my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, ill dig out the number 13:38
no trial for that
split dosing has no trial behind it. people here do it and report on it, thats all
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i would hold
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does a missed week reset anything or do you just carry on
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, ill dig out the number
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
how do you tell a plateau from just being at your set point
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pick a day and stick to it
sorry to jump in stepping back down on purpose is a completely reasonable move and this channel should say so more often
came down, no regrets
go slower
with a roughly seven day half-life you are near steady state after about five weeks at a dose
while im here i went from 15 to 0.25 and honestly could not tell the difference in appetite
if i hold at 2 indefinitely am i losing anything
what does the room think about jumping a rung to catch up
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genuine question i drifted from sunday to wednesday over a year and only noticed when i checked the log
whats the smallest step anyone has managed between doses
right so if it "stopped working after four days" that is almost never pharmacokinetics
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
held for months
for the archive anyone tracked whether a smaller more frequent dose changed their side effects
do you tell your prescriber you held or do you just hold
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while im here if the current dose is still working, going up is spending headroom you might want later
the trials escalated on a fixed schedule because a trial has to. you are not a trial
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do you count from injection day or from when you actually felt it
plateau versus set point is not answerable in under six months of data
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the honest answer is that most of us are running protocols nobody has ever studied
hold
came down from a treatment dose to maintenance over about three months and it was uneventful
[edited]two weeks is nothing
sorry to jump in appetite returning at the end of the week is extremely common and is not the dose failing
whats your rule for when a side effect means hold rather than push
update from 7 months ago: held at the same dose the whole time and still losing slowly
nobody here can tell you what dose to be on and the ones who try get corrected
how do you decide between holding and stepping when both feel wrong
i escalate on symptoms. if the current dose is still doing something i stay on it
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follow up after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice