held for months
#dosing-titration 2026-03-10
Tuesday22 messages5 participantstimes are UTC
Highlights from this day
- vial_ledger — slightly off topic but do you count from injection day or from when you actually felt it 17:09
- slow.taper — the trials escalated on a fixed schedule because a trial has to. you are not a trial 18:54
- triple_ag_tom — you do not have to escalate at all. that is a real option that gets forgotten 19:52
do you escalate on the calendar or on how you feel
came down, no regrets
for the archive i went from 7.5 to 0.5 and honestly could not tell the difference in appetite, i could be wrong
slightly off topic but do you count from injection day or from when you actually felt it
💀14🧊18🙏4
i would hold
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
right so do you tell your prescriber you held or do you just hold
thats anecdote
how do you decide between holding and stepping when both feel wrong
anyone here split their weekly into two and would they do it again
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
with a roughly seven day half-life you are near steady state after about five weeks at a dose, anyway
the trials escalated on a fixed schedule because a trial has to. you are not a trial
👀10
end of week thing
n of 1
whats your rule for when a side effect means hold rather than push
i went up too fast and im paying for it, do i drop back or ride it out
you do not have to escalate at all. that is a real option that gets forgotten
🔥9
i have been at 2.5 for 13 months and honestly i have stopped wanting to move
two weeks is nothing
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
has anyone gone up and then straight back down and been glad they tried