#dosing-titration 2026-03-01

slightly off topic but i escalate on symptoms. if the current dose is still doing something i stay on it

anyone tracked whether a smaller more frequent dose changed their side effects

if you are asking whether to go up, the fact you are asking usually means not yet, ymmv

i drifted from sunday to wednesday over a year and only noticed when i checked the log

after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice

not advice

follow up with a roughly seven day half-life you are near steady state after about five weeks at a dose

pick a day and stick to it

coming back to this holding is not failing. most people here who lasted two years held at least one dose for months

i hold for two months minimum before i decide a dose has stopped doing anything, ill dig out the number

ok so the honest answer is that most of us are running protocols nobody has ever studied

i went from 0.25 to 5 and honestly could not tell the difference in appetite

a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored

quick one nobody here can tell you what dose to be on and the ones who try get corrected

no trial for that