came down, no regrets
#dosing-titration 2026-02-21
Saturday52 messages9 participantstimes are UTC
Highlights from this day
- patent_2026 — my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step 22:14
- step_one_sian — i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat a missed week does not reset you, but going straight back to the top dose… 22:23
- patent_2026 — update on the earlier thing i log dose, day, weight and one line about how the week felt. thats enough to make decisions on 22:36
- u100_pat — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice 23:05
- plateau_pen — dose day drift is mostly harmless with a weekly compound, but pick a day and defend it i drifted from sunday to wednesday over a year and only noticed when i checked… 23:27
you do not have to escalate at all. that is a real option that gets forgotten
i have been at 5 for 7 months and honestly i have stopped wanting to move
if i hold at 0.25 indefinitely am i losing anything
thats anecdote
steady state is 5 weeks
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)i would hold
holding is not failing. most people here who lasted two years held at least one dose for months
whats the longest anyone has stayed on one dose
not advice
end of week thing
if it "stopped working after four days" that is almost never pharmacokinetics
how much does the last dose still matter 6 days later
for the archive i drifted from sunday to wednesday over a year and only noticed when i checked the log
i went from 7.5 to 2.5 and honestly could not tell the difference in appetite
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
lot-log.csv
726 rows · not retained in the public archive
is it normal for appetite to come back at the end of the week
hold
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
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unrelated but whats a sensible maintenance dose after a year at treatment dose
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
the people who do best here are almost always the ones going slowest
n of 1
thats normal
update on the earlier thing is there a trial anywhere that studied twice weekly, or is it all anecdote
stepping back down on purpose is a completely reasonable move and this channel should say so more often
update on the earlier thing i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
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small steps are better than big ones and the only reason people take big ones is impatience
[edited]nobody here can tell you what dose to be on and the ones who try get corrected
if the current dose is still working, going up is spending headroom you might want later
the honest answer is that most of us are running protocols nobody has ever studied
too early imo
how do you decide between holding and stepping when both feel wrong
go slower
held for months
the ladder in the trials is a starting point, not a schedule you owe anyone
came down from a treatment dose to maintenance over about three months and it was uneventful
split dosing has no trial behind it. people here do it and report on it, thats all
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgif you are going up because the scale stalled for two weeks, wait. two weeks is noise
half life is a week
appetite returning at the end of the week is extremely common and is not the dose failing
with a roughly seven day half-life you are near steady state after about five weeks at a dose, i have it written down somewhere
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
whats your rule for when a side effect means hold rather than push
if you are asking whether to go up, the fact you are asking usually means not yet
while im here i escalate on symptoms. if the current dose is still doing something i stay on it
thats noise
*that should say weekly
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
i drifted from sunday to wednesday over a year and only noticed when i checked the log
i hold for two months minimum before i decide a dose has stopped doing anything, someone check my working