how do you tell a plateau from just being at your set point
#dosing-titration 2026-02-08
Sunday28 messages7 participantstimes are UTC
Highlights from this day
- meal_prep_mick — a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored 11:25
- first_month_fi — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice 13:42
- spreadsheet_stu — slightly off topic but with a roughly seven day half-life you are near steady state after about five weeks at a dose 13:46
my titration ladder took 9 months to climb and i would do it slower again
the trials escalated on a fixed schedule because a trial has to. you are not a trial
i escalate on symptoms. if the current dose is still doing something i stay on it, not advice obviously
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
is week 23 too early to be thinking about the next step
if i took it 2 days late do i shift the schedule or go back to the old day
do you tell your prescriber you held or do you just hold
i have been at 5 for 9 months and honestly i have stopped wanting to move
too early imo
follow up plateau versus set point is not answerable in under six months of data
thats normal
is it normal for appetite to come back at the end of the week
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
hold
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg🙏8💀14
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
slightly off topic but with a roughly seven day half-life you are near steady state after about five weeks at a dose
janoshik-e-2205.pdf
2 pages · 225 KB · not retained in the public archive
🧊4📉6
n of 1
end of week thing
do you escalate on the calendar or on how you feel
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, not advice obviously
[edited]nobody here can tell you what dose to be on and the ones who try get corrected
update from 21 months ago: held at the same dose the whole time and still losing slowly, ill dig out the number
the ladder in the trials is a starting point, not a schedule you owe anyone
steady state is 5 weeks
slightly off topic but i went from 5 to 0.5 and honestly could not tell the difference in appetite
small steps are better than big ones and the only reason people take big ones is impatience