nobody here can tell you what dose to be on and the ones who try get corrected, we shall see
#dosing-titration 2026-01-31
Saturday33 messages8 participantstimes are UTC
Highlights from this day
- mag_citrate — my dose day has drifted 2 days later over 17 months, does it matter if it "stopped working after four days" that is almost never pharmacokinetics 18:06
- VialBot — Testing queue: 3 submissions open, 127 awaiting dispatch. 18:37
- pin29g — what does the room think about jumping a rung to catch up 18:46
- u100_pat — slightly off topic but my titration ladder took 6 months to climb and i would do it slower again 19:56
if the current dose is still working, going up is spending headroom you might want later
i hold for two months minimum before i decide a dose has stopped doing anything
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
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go slower
my dose day has drifted 2 days later over 17 months, does it matter
if it "stopped working after four days" that is almost never pharmacokinetics
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split dosing has no trial behind it. people here do it and report on it, thats all
is it normal for appetite to come back at the end of the week
unrelated but appetite returning at the end of the week is extremely common and is not the dose failing, i could be wrong
if the current dose is still working, going up is spending headroom you might want later
Testing queue: 3 submissions open, 127 awaiting dispatch.
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stepping back down on purpose is a completely reasonable move and this channel should say so more often
what does the room think about jumping a rung to catch up
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the honest answer is that most of us are running protocols nobody has ever studied
came down, no regrets
thats noise
too early imo
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the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
i would hold
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pick a day and stick to it
the people who do best here are almost always the ones going slowest
half life is a week
if it "stopped working after four days" that is almost never pharmacokinetics
holding is not failing. most people here who lasted two years held at least one dose for months
update on the earlier thing the trials escalated on a fixed schedule because a trial has to. you are not a trial
not advice
anyone here split their weekly into two and would they do it again
slightly off topic but my titration ladder took 6 months to climb and i would do it slower again
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holding is not failing. most people here who lasted two years held at least one dose for months
steady state is 5 weeks
end of week thing
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
you do not have to escalate at all. that is a real option that gets forgotten
thats anecdote
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i drifted from sunday to wednesday over a year and only noticed when i checked the log