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#dosing-titration 2026-01-07
Wednesday24 messages4 participantstimes are UTC
Highlights from this day
- VialBot — Recon calculator: 20mg in 2.5ml = 2.5mg/ml. 20:01
- VialBot — Reminder for mag_citrate: dose day is today. Set 5 days ago. 21:02
- mag_citrate — the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess 21:05
- mag_citrate — i log dose, day, weight and one line about how the week felt. thats enough to make decisions on 22:12
came down from a treatment dose to maintenance over about three months and it was uneventful
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
while im here what does the room think about jumping a rung to catch up
sorry to jump in i drifted from sunday to wednesday over a year and only noticed when i checked the log
is week 5 too early to be thinking about the next step
do you escalate on the calendar or on how you feel
whats your rule for when a side effect means hold rather than push
my titration ladder took 23 months to climb and i would do it slower again
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the trials escalated on a fixed schedule because a trial has to. you are not a trial
Recon calculator: 20mg in 2.5ml = 2.5mg/ml.
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i would hold
update from 1 months ago: held at the same dose the whole time and still losing slowly
i went from 2 to 1 and honestly could not tell the difference in appetite
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the honest answer is that most of us are running protocols nobody has ever studied, your mileage will differ
split dosing has no trial behind it. people here do it and report on it, thats all
Reminder for mag_citrate: dose day is today. Set 5 days ago.
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the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
you do not have to escalate at all. that is a real option that gets forgotten, for what its worth
[edited]a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
holding is not failing. most people here who lasted two years held at least one dose for months
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
stepping back down on purpose is a completely reasonable move and this channel should say so more often
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
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if you are asking whether to go up, the fact you are asking usually means not yet