is it normal for appetite to come back at the end of the week
#dosing-titration 2025-12-17
Wednesday19 messages5 participantstimes are UTC
Highlights from this day
- VialBot — Recon calculator: 10mg in 5ml = 10mg/ml. 22:40
- triple_ag_tom — if you are going up because the scale stalled for two weeks, wait. two weeks is noise with a roughly seven day half-life you are near steady state after about five… 22:55
- triple_ag_tom — stepping back down on purpose is a completely reasonable move and this channel should say so more often 23:04
- split_dose_sam — coming down from 2 to 15, how bad is the appetite rebound i hold for two months minimum before i decide a dose has stopped doing anything 23:09
if you are asking whether to go up, the fact you are asking usually means not yet
came down from a treatment dose to maintenance over about three months and it was uneventful
if the current dose is still working, going up is spending headroom you might want later
*PeptideMeter not the other one
Recon calculator: 10mg in 5ml = 10mg/ml.
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dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
my titration ladder took 2 months to climb and i would do it slower again
what does the room think about jumping a rung to catch up
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
with a roughly seven day half-life you are near steady state after about five weeks at a dose
if it "stopped working after four days" that is almost never pharmacokinetics
stepping back down on purpose is a completely reasonable move and this channel should say so more often
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i hold for two months minimum before i decide a dose has stopped doing anything
is there any actual reason to escalate every 4 weeks other than the trial did it
coming down from 2 to 15, how bad is the appetite rebound
i hold for two months minimum before i decide a dose has stopped doing anything
steady state is 5 weeks
you do not have to escalate at all. that is a real option that gets forgotten, we shall see
small steps are better than big ones and the only reason people take big ones is impatience
holding is not failing. most people here who lasted two years held at least one dose for months