if you are going up because the scale stalled for two weeks, wait. two weeks is noise
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mg#dosing-titration 2025-11-30
Sunday27 messages7 participantstimes are UTC
Highlights from this day
- mcg_not_mg — if you are going up because the scale stalled for two weeks, wait. two weeks is noise 20:51
- typosquat_tay — is week 31 too early to be thinking about the next step 21:11
- typosquat_tay — what does the room think about jumping a rung to catch up 21:22
- mcg_not_mg — for the archive my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step with a roughly seven day half-life you are near steady… 21:40
came down, no regrets
if i hold at 2.4 indefinitely am i losing anything
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i escalate on symptoms. if the current dose is still doing something i stay on it
i would hold
came down from a treatment dose to maintenance over about three months and it was uneventful
is week 31 too early to be thinking about the next step
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whats the smallest step anyone has managed between doses
i drifted from sunday to wednesday over a year and only noticed when i checked the log
what does the room think about jumping a rung to catch up
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holding is not failing. most people here who lasted two years held at least one dose for months
for the archive my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
with a roughly seven day half-life you are near steady state after about five weeks at a dose
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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whats the longest anyone has stayed on one dose
update question: did anyone who held for 16 months regret it
Batch lookup B-0329: 5 independent reports on file, earliest 2025-07-31.
if you are asking whether to go up, the fact you are asking usually means not yet
Testing queue: 9 submissions open, 100 awaiting dispatch.
pick a day and stick to it
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n of 1
hold
small steps are better than big ones and the only reason people take big ones is impatience
how long did you hold at 1.7 before you moved up
if the current dose is still working, going up is spending headroom you might want later
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thats normal
the trials escalated on a fixed schedule because a trial has to. you are not a trial
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