is week 25 too early to be thinking about the next step
#dosing-titration 2025-11-15
Saturday32 messages10 participantstimes are UTC
Highlights from this day
- swab_dry_first — the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess 13:54
- swab_dry_first — i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else, from memory 13:59
- taipei_tare — is there a point where going up stops buying you anything 14:23
- split_dose_sam — i escalate on symptoms. if the current dose is still doing something i stay on it 15:13
- VialBot — New independent result logged — ERP, lot KP-0925, purity 97.4% (Janoshik). 19:30
what does the room think about jumping a rung to catch up
holding is not failing. most people here who lasted two years held at least one dose for months, thats just me
do you escalate on the calendar or on how you feel
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
go slower
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i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else, from memory
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
is there a point where going up stops buying you anything
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how much does the last dose still matter 6 days later
is it normal for appetite to come back at the end of the week
genuine question anyone here split their weekly into two and would they do it again
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
thats anecdote
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i escalate on symptoms. if the current dose is still doing something i stay on it
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slightly off topic but update question: did anyone who held for 20 months regret it
if you are asking whether to go up, the fact you are asking usually means not yet
i would hold
coming back to this is there a trial anywhere that studied twice weekly, or is it all anecdote
i went up too fast and im paying for it, do i drop back or ride it out
[edited]half life is a week
right so my titration ladder took 1 months to climb and i would do it slower again
hold
how do you decide between holding and stepping when both feel wrong
end of week thing
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sorry to jump in does a missed week reset anything or do you just carry on
the ladder in the trials is a starting point, not a schedule you owe anyone
New independent result logged — ERP, lot KP-0925, purity 97.4% (Janoshik).
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too early imo
two weeks is nothing
the honest answer is that most of us are running protocols nobody has ever studied