if the current dose is still working, going up is spending headroom you might want later
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#dosing-titration 2025-10-26
Sunday42 messages10 participantstimes are UTC
Highlights from this day
- noct.titrate — if the current dose is still working, going up is spending headroom you might want later 17:17
- slow.taper — i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else 17:31
- spreadsheet_stu — has anyone gone up and then straight back down and been glad they tried 19:07
- noct.titrate — ok so my dose day has drifted 7 days later over 12 months, does it matter 19:50
- VialBot — Testing queue: 6 submissions open, 137 awaiting dispatch. 23:31
steady state is 5 weeks
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i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
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half life is a week
i went up too fast and im paying for it, do i drop back or ride it out
if it "stopped working after four days" that is almost never pharmacokinetics
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it, still working it out
anyone tracked whether a smaller more frequent dose changed their side effects
[edited]i hold for two months minimum before i decide a dose has stopped doing anything
noct.titrateif the current dose is still working, going up is spending headroom you might want later
stepping back down on purpose is a completely reasonable move and this channel should say so more often
holding is not failing. most people here who lasted two years held at least one dose for months
if i hold at 2.4 indefinitely am i losing anything
[edited]a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
coming down from 10 to 2, how bad is the appetite rebound
too early imo
quick one do you escalate on the calendar or on how you feel
thats normal
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i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat, your mileage will differ
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after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
appetite returning at the end of the week is extremely common and is not the dose failing
has anyone gone up and then straight back down and been glad they tried
U-100 syringe: 1 unit = 0.01 ml
10u = 0.10 ml
25u = 0.25 ml
50u = 0.50 ml
100u = 1.00 ml
mg drawn = ml drawn x mg/mlslightly off topic but update from 13 months ago: held at the same dose the whole time and still losing slowly
*PeptideMeter not the other one
end of week thing
i would hold
[edited]coming back to this is there a trial anywhere that studied twice weekly, or is it all anecdote
coming back to this appetite returning at the end of the week is extremely common and is not the dose failing
anyone here split their weekly into two and would they do it again
came down from a treatment dose to maintenance over about three months and it was uneventful
ok so my dose day has drifted 7 days later over 12 months, does it matter
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my titration ladder took 18 months to climb and i would do it slower again
genuine question i drifted from sunday to wednesday over a year and only noticed when i checked the log, thats one data point
the honest answer is that most of us are running protocols nobody has ever studied
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two weeks is nothing
plateau versus set point is not answerable in under six months of data, anyway
i went from 2.5 to 15 and honestly could not tell the difference in appetite
how do you tell a plateau from just being at your set point
do you tell your prescriber you held or do you just hold
held for months
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the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess, anyway
[edited]if you are going up because the scale stalled for two weeks, wait. two weeks is noise, someone check my working
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go slower
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Testing queue: 6 submissions open, 137 awaiting dispatch.
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