i went up too fast and im paying for it, do i drop back or ride it out
[edited]❤️17⚠️14
#dosing-titration 2025-10-22
Wednesday14 messages3 participantstimes are UTC
Highlights from this day
- first_month_fi — i went up too fast and im paying for it, do i drop back or ride it out 07:22
- stack_sceptic — do you tell your prescriber you held or do you just hold 08:59
- first_month_fi — ok so i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else 09:43
came down from a treatment dose to maintenance over about three months and it was uneventful
with a roughly seven day half-life you are near steady state after about five weeks at a dose
ok so update question: did anyone who held for 20 months regret it
do you tell your prescriber you held or do you just hold
[edited]| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
ok so i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
split dosing has no trial behind it. people here do it and report on it, thats all, from memory
plateau versus set point is not answerable in under six months of data
follow up stepping back down on purpose is a completely reasonable move and this channel should say so more often
unrelated but my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
is there a trial anywhere that studied twice weekly, or is it all anecdote
unrelated but my titration ladder took 9 months to climb and i would do it slower again
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
[edited]the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess