i drifted from sunday to wednesday over a year and only noticed when i checked the log
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#dosing-titration 2025-10-09
Thursday27 messages8 participantstimes are UTC
Highlights from this day
- first_and_last_four — appetite returning at the end of the week is extremely common and is not the dose failing, take that with a pinch of salt 19:27
- night_pin — if you are going up because the scale stalled for two weeks, wait. two weeks is noise, ask me again in a month 20:01
- private_script_pri — holding is not failing. most people here who lasted two years held at least one dose for months 21:58
appetite returning at the end of the week is extremely common and is not the dose failing, take that with a pinch of salt
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split dosing has no trial behind it. people here do it and report on it, thats all
came down from a treatment dose to maintenance over about three months and it was uneventful
do you escalate on the calendar or on how you feel
genuine question i have been at 0.25 for 17 months and honestly i have stopped wanting to move
if you are going up because the scale stalled for two weeks, wait. two weeks is noise, ask me again in a month
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quick one the honest answer is that most of us are running protocols nobody has ever studied
thats noise
if i hold at 12 indefinitely am i losing anything
coming back to this my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, ill dig out the number
Testing queue: 9 submissions open, 70 awaiting dispatch.
unrelated but if i took it 2 days late do i shift the schedule or go back to the old day
if the current dose is still working, going up is spending headroom you might want later
steady state is 5 weeks
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
end of week thing
plateau versus set point is not answerable in under six months of data
is week 31 too early to be thinking about the next step
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thats anecdote
half life is a week
whats a sensible maintenance dose after a year at treatment dose
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holding is not failing. most people here who lasted two years held at least one dose for months
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do you count from injection day or from when you actually felt it
i escalate on symptoms. if the current dose is still doing something i stay on it
the ladder in the trials is a starting point, not a schedule you owe anyone, ask me again in a month
stepping back down on purpose is a completely reasonable move and this channel should say so more often
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