quick one is it normal for appetite to come back at the end of the week
#dosing-titration 2025-08-20
Wednesday29 messages5 participantstimes are UTC
Highlights from this day
- mg_per_ml — i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else 18:45
- mg_per_ml — a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored 19:32
- sgp_subq — whats the longest anyone has stayed on one dose 19:54
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
if i took it 5 days late do i shift the schedule or go back to the old day
[edited]i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
i have been at 5 for 21 months and honestly i have stopped wanting to move
update from 21 months ago: held at the same dose the whole time and still losing slowly
what does the room think about jumping a rung to catch up
with a roughly seven day half-life you are near steady state after about five weeks at a dose
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
holding is not failing. most people here who lasted two years held at least one dose for months
my titration ladder took 20 months to climb and i would do it slower again, for what its worth
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
the trials escalated on a fixed schedule because a trial has to. you are not a trial
came down, no regrets
[edited]if you are asking whether to go up, the fact you are asking usually means not yet
whats your rule for when a side effect means hold rather than push
whats the longest anyone has stayed on one dose
🙏4
end of week thing
half life is a week
🙏1🔥4
small steps are better than big ones and the only reason people take big ones is impatience
you do not have to escalate at all. that is a real option that gets forgotten
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
how do you decide between holding and stepping when both feel wrong
thats noise
medutest-report-e-2205.pdf
3 pages · 515 KB · not retained in the public archive
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
two weeks is nothing
the people who do best here are almost always the ones going slowest
the honest answer is that most of us are running protocols nobody has ever studied