my titration ladder took 24 months to climb and i would do it slower again
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#dosing-titration 2025-08-09
Saturday34 messages7 participantstimes are UTC
Highlights from this day
- plateau_pen — my titration ladder took 24 months to climb and i would do it slower again 11:21
- ghk_gia — if i hold at 10 indefinitely am i losing anything 11:25
- plateau_pen — appetite returning at the end of the week is extremely common and is not the dose failing 11:32
- seizure_letter — ok so the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess 13:54
if i hold at 10 indefinitely am i losing anything
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appetite returning at the end of the week is extremely common and is not the dose failing
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[redacted at member request] · archive policy
hold
is week 6 too early to be thinking about the next step
came down, no regrets
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
my dose day has drifted 3 days later over 10 months, does it matter
thats normal
go slower
do you tell your prescriber you held or do you just hold
the honest answer is that most of us are running protocols nobody has ever studied
plateau versus set point is not answerable in under six months of data
how much does the last dose still matter 8 days later
you do not have to escalate at all. that is a real option that gets forgotten
right so whats your rule for when a side effect means hold rather than push
coming back to this if the current dose is still working, going up is spending headroom you might want later
i drifted from sunday to wednesday over a year and only noticed when i checked the log
is it normal for appetite to come back at the end of the week
update from 13 months ago: held at the same dose the whole time and still losing slowly, take that with a pinch of salt
ok so the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
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the trials escalated on a fixed schedule because a trial has to. you are not a trial
pick a day and stick to it
if it "stopped working after four days" that is almost never pharmacokinetics
n of 1
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steady state is 5 weeks
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)two weeks is nothing
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i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
is there any actual reason to escalate every 4 weeks other than the trial did it
held for months
not advice
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coming down from 1.7 to 7.5, how bad is the appetite rebound
coming back to this after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice