no trial for that
Cited study
Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1)
New England Journal of Medicine · 2022
72 weeks, tirzepatide 5, 10 and 15mg against placebo.
no trial for that
*that should say weekly
two weeks is nothing
Verification log updated: QYB — evidence added, status unchanged.
i would hold
the honest answer is that most of us are running protocols nobody has ever studied
does a missed week reset anything or do you just carry on
whats your rule for when a side effect means hold rather than push
*Medutest not the other one
follow up you do not have to escalate at all. that is a real option that gets forgotten, your mileage will differ
small steps are better than big ones and the only reason people take big ones is impatience
stepping back down on purpose is a completely reasonable move and this channel should say so more often
is there a trial anywhere that studied twice weekly, or is it all anecdote
how do you tell a plateau from just being at your set point
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
Verification log updated: GL Biochem — evidence added, status unchanged.
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
end of week thing
[edited]n of 1
do you escalate on the calendar or on how you feel
quick one update question: did anyone who held for 7 months regret it
i have been at 10 for 23 months and honestly i have stopped wanting to move
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
i went from 0.5 to 5 and honestly could not tell the difference in appetite
anyone here split their weekly into two and would they do it again
the trials escalated on a fixed schedule because a trial has to. you are not a trial
whats the smallest step anyone has managed between doses
go slower
thats normal
thats noise
came down, no regrets
the ladder in the trials is a starting point, not a schedule you owe anyone, not advice obviously
with a roughly seven day half-life you are near steady state after about five weeks at a dose
i escalate on symptoms. if the current dose is still doing something i stay on it
if the current dose is still working, going up is spending headroom you might want later, happy to be corrected
is week 32 too early to be thinking about the next step
half life is a week
whats a sensible maintenance dose after a year at treatment dose
update from 11 months ago: held at the same dose the whole time and still losing slowly
if i hold at 15 indefinitely am i losing anything
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, take that with a pinch of salt
right so i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
the people who do best here are almost always the ones going slowest
holding is not failing. most people here who lasted two years held at least one dose for months
holding is not failing. most people here who lasted two years held at least one dose for months
update from 9 months ago: held at the same dose the whole time and still losing slowly
if you are asking whether to go up, the fact you are asking usually means not yet
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
how do you decide between holding and stepping when both feel wrong
held for months
steady state is 5 weeks
too early imo
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored, take that with a pinch of salt
hold