do you count from injection day or from when you actually felt it
#dosing-titration 2025-07-21
Monday27 messages4 participantstimes are UTC
Highlights from this day
- seven_five_sweet — is there any actual reason to escalate every 4 weeks other than the trial did it 20:04
- mhra_unlicensed — for the archive the people who do best here are almost always the ones going slowest 20:31
- mhra_unlicensed — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice 21:16
- ms_ms_mira — whats the longest anyone has stayed on one dose 21:20
is there any actual reason to escalate every 4 weeks other than the trial did it
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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do you escalate on the calendar or on how you feel
is there a trial anywhere that studied twice weekly, or is it all anecdote
came down, no regrets
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if you are going up because the scale stalled for two weeks, wait. two weeks is noise
held for months
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i escalate on symptoms. if the current dose is still doing something i stay on it
the trials escalated on a fixed schedule because a trial has to. you are not a trial
stepping back down on purpose is a completely reasonable move and this channel should say so more often
for the archive the people who do best here are almost always the ones going slowest
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too early imo
the honest answer is that most of us are running protocols nobody has ever studied, for what its worth
you do not have to escalate at all. that is a real option that gets forgotten, happy to be corrected
what does the room think about jumping a rung to catch up
i hold for two months minimum before i decide a dose has stopped doing anything
genuine question a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
split dosing has no trial behind it. people here do it and report on it, thats all
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
quick one has anyone gone up and then straight back down and been glad they tried
whats the longest anyone has stayed on one dose
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i would hold
if it "stopped working after four days" that is almost never pharmacokinetics
the trials escalated on a fixed schedule because a trial has to. you are not a trial
came down from a treatment dose to maintenance over about three months and it was uneventful
unrelated but plateau versus set point is not answerable in under six months of data
update from 14 months ago: held at the same dose the whole time and still losing slowly
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*Medutest not the other one