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#dosing-titration 2025-07-15
Tuesday20 messages5 participantstimes are UTC
Highlights from this day
- step_one_sian — i went from 2 to 10 and honestly could not tell the difference in appetite 19:38
- step_one_sian — whats a sensible maintenance dose after a year at treatment dose 20:06
- customs_owl — update from 12 months ago: held at the same dose the whole time and still losing slowly, for what its worth 20:13
- customs_owl — for the archive with a roughly seven day half-life you are near steady state after about five weeks at a dose update from 12 months ago: held at the same dose the… 20:16
no trial for that
plateau versus set point is not answerable in under six months of data, we shall see
i drifted from sunday to wednesday over a year and only noticed when i checked the log
i would hold
i hold for two months minimum before i decide a dose has stopped doing anything
held for months
how do you decide between holding and stepping when both feel wrong
is there a point where going up stops buying you anything
nobody here can tell you what dose to be on and the ones who try get corrected
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i went from 2 to 10 and honestly could not tell the difference in appetite
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whats a sensible maintenance dose after a year at treatment dose
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
not advice
end of week thing
update from 12 months ago: held at the same dose the whole time and still losing slowly, for what its worth
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for the archive with a roughly seven day half-life you are near steady state after about five weeks at a dose
update from 12 months ago: held at the same dose the whole time and still losing slowly
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mgwhats the longest anyone has stayed on one dose
if it "stopped working after four days" that is almost never pharmacokinetics
do you tell your prescriber you held or do you just hold
pick a day and stick to it