vialroom

#dosing-titration 2025-07-12

Saturday31 messages7 participantstimes are UTC
Highlights from this day
  • two_lifts_a_week — i log dose, day, weight and one line about how the week felt. thats enough to make decisions on 18:45
  • per_mg_pete — i drifted from sunday to wednesday over a year and only noticed when i checked the log, from memory 19:27
  • per_mg_pete — is there a point where going up stops buying you anything 20:03
SH

follow up a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored

PB

holding is not failing. most people here who lasted two years held at least one dose for months, take that with a pinch of salt

SH

i escalate on symptoms. if the current dose is still doing something i stay on it, thats just me

TL

i log dose, day, weight and one line about how the week felt. thats enough to make decisions on

👍11

update from 2 months ago: held at the same dose the whole time and still losing slowly

no trial for that

hold

FI

unrelated but if i took it 2 days late do i shift the schedule or go back to the old day

appetite returning at the end of the week is extremely common and is not the dose failing

PM

i drifted from sunday to wednesday over a year and only noticed when i checked the log, from memory

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PM

the trials escalated on a fixed schedule because a trial has to. you are not a trial

SH

pick a day and stick to it

U-100 syringe: 1 unit = 0.01 ml
  10u = 0.10 ml
  25u = 0.25 ml
  50u = 0.50 ml
 100u = 1.00 ml
mg drawn = ml drawn x mg/ml
PM

is there a point where going up stops buying you anything

Cited study
Effect of Continued Weekly Semaglutide vs Placebo on Weight Loss Maintenance (STEP 4)
JAMA · 2021
The withdrawal arm. This is the trial to read before you plan to stop.
PM

genuine question small steps are better than big ones and the only reason people take big ones is impatience

[edited]
NT

how long did you hold at 5 before you moved up
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess

MM

update on the earlier thing plateau versus set point is not answerable in under six months of data

MM

stepping back down on purpose is a completely reasonable move and this channel should say so more often

FI

quick one the honest answer is that most of us are running protocols nobody has ever studied, still working it out

FI

i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else