update on the earlier thing nobody here can tell you what dose to be on and the ones who try get corrected
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#dosing-titration 2025-06-29
Sunday13 messages5 participantstimes are UTC
Highlights from this day
- sharps_bin_sid — update on the earlier thing nobody here can tell you what dose to be on and the ones who try get corrected 12:51
- sharps_bin_sid — genuine question is it normal for appetite to come back at the end of the week i escalate on symptoms. if the current dose is still doing something i stay on it 13:46
- lisbon_lot — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice 14:31
genuine question is it normal for appetite to come back at the end of the week
i escalate on symptoms. if the current dose is still doing something i stay on it
stepping back down on purpose is a completely reasonable move and this channel should say so more often
pick a day and stick to it
thats noise
the ladder in the trials is a starting point, not a schedule you owe anyone
end of week thing
anyone here split their weekly into two and would they do it again
with a roughly seven day half-life you are near steady state after about five weeks at a dose
holding is not failing. most people here who lasted two years held at least one dose for months, not advice obviously
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
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you do not have to escalate at all. that is a real option that gets forgotten
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else, not advice obviously