i drifted from sunday to wednesday over a year and only noticed when i checked the log, i think
#dosing-titration 2025-06-26
Thursday41 messages9 participantstimes are UTC
Highlights from this day
- sulphur_burp — the ladder in the trials is a starting point, not a schedule you owe anyone, take that with a pinch of salt 14:10
- underfill_uma — plateau versus set point is not answerable in under six months of data 17:24
- underfill_uma — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice 18:09
whats the longest anyone has stayed on one dose
has anyone gone up and then straight back down and been glad they tried
thats normal
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coming back to this the honest answer is that most of us are running protocols nobody has ever studied
two weeks is nothing
holding is not failing. most people here who lasted two years held at least one dose for months
i hold for two months minimum before i decide a dose has stopped doing anything, anyway
my titration ladder took 22 months to climb and i would do it slower again
i escalate on symptoms. if the current dose is still doing something i stay on it, not advice obviously
hold
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steady state is 5 weeks
my titration ladder took 13 months to climb and i would do it slower again, someone check my working
if i took it 4 days late do i shift the schedule or go back to the old day
came down from a treatment dose to maintenance over about three months and it was uneventful
is there a trial anywhere that studied twice weekly, or is it all anecdote
the ladder in the trials is a starting point, not a schedule you owe anyone, take that with a pinch of salt
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came down, no regrets
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thats noise
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with a roughly seven day half-life you are near steady state after about five weeks at a dose
my dose day has drifted 3 days later over 5 months, does it matter
Inter-lab diff for lot H-2814: 97.4% vs 99.2%. Within expected range.
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, your mileage will differ
is it normal for appetite to come back at the end of the week
the trials escalated on a fixed schedule because a trial has to. you are not a trial
i would hold
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Reminder for net_peptide: dose day is today. Set 2 days ago.
end of week thing
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split dosing has no trial behind it. people here do it and report on it, thats all, ymmv
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thats anecdote
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while im here do you escalate on the calendar or on how you feel
whats your rule for when a side effect means hold rather than push
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
plateau versus set point is not answerable in under six months of data
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coming back to this the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
while im here update from 8 months ago: held at the same dose the whole time and still losing slowly
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
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appetite returning at the end of the week is extremely common and is not the dose failing
nobody here can tell you what dose to be on and the ones who try get corrected
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
do you tell your prescriber you held or do you just hold
half life is a week
if it "stopped working after four days" that is almost never pharmacokinetics, someone check my working