follow up a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
#dosing-titration 2025-05-23
Friday24 messages4 participantstimes are UTC
Highlights from this day
- bac_water_bill — follow up a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored 09:29
- bac_water_bill — my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step 10:01
- shame_and_meds — dose day drift is mostly harmless with a weekly compound, but pick a day and defend it 10:05
- no_escrow_nate — if you are going up because the scale stalled for two weeks, wait. two weeks is noise 13:09
- shame_and_meds — if it "stopped working after four days" that is almost never pharmacokinetics 13:13
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
the people who do best here are almost always the ones going slowest
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
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too early imo
steady state is 5 weeks
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if the current dose is still working, going up is spending headroom you might want later
i hold for two months minimum before i decide a dose has stopped doing anything
pick a day and stick to it
hold
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do you tell your prescriber you held or do you just hold
is there a point where going up stops buying you anything
do you escalate on the calendar or on how you feel
appetite returning at the end of the week is extremely common and is not the dose failing
how do you decide between holding and stepping when both feel wrong
is there any actual reason to escalate every 4 weeks other than the trial did it
is it normal for appetite to come back at the end of the week
half life is a week
go slower
transit-times.csv
152 rows · not retained in the public archive
the trials escalated on a fixed schedule because a trial has to. you are not a trial
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
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i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
if it "stopped working after four days" that is almost never pharmacokinetics
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with a roughly seven day half-life you are near steady state after about five weeks at a dose