vialroom

#dosing-titration 2025-05-13

Tuesday24 messages7 participantstimes are UTC
Highlights from this day
  • area_percent — if i took it 2 days late do i shift the schedule or go back to the old day 22:15
  • VialBot — Assay note: GGPeps lot B-0114 reported at 98.1% of label content. 22:17
  • VialBot — Batch lookup H-2814: 7 independent reports on file, earliest 2024-08-17. 22:34
  • pinch_not_stretch — the trials escalated on a fixed schedule because a trial has to. you are not a trial 22:56
  • pinch_not_stretch — with a roughly seven day half-life you are near steady state after about five weeks at a dose 23:00

how do you tell a plateau from just being at your set point

genuine question whats the longest anyone has stayed on one dose

SB

is it normal for appetite to come back at the end of the week

peptidemeter-summary-f-1330.pdf
2 pages · 794 KB · not retained in the public archive
DE

if you are going up because the scale stalled for two weeks, wait. two weeks is noise

PN

appetite returning at the end of the week is extremely common and is not the dose failing

VB

Assay note: GGPeps lot B-0114 reported at 98.1% of label content.

AP

you do not have to escalate at all. that is a real option that gets forgotten, someone check my working

AP

i have been at 2 for 7 months and honestly i have stopped wanting to move

MM

is there a trial anywhere that studied twice weekly, or is it all anecdote
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice

VB

Batch lookup H-2814: 7 independent reports on file, earliest 2024-08-17.

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go slower

i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat

sorry to jump in i escalate on symptoms. if the current dose is still doing something i stay on it

PN

the trials escalated on a fixed schedule because a trial has to. you are not a trial

Cited study
Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1)
New England Journal of Medicine · 2022
72 weeks, tirzepatide 5, 10 and 15mg against placebo.

genuine question whats the smallest step anyone has managed between doses

*Medutest not the other one

with a roughly seven day half-life you are near steady state after about five weeks at a dose

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