after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
#dosing-titration 2025-05-10
Saturday23 messages6 participantstimes are UTC
Highlights from this day
- rezept_rolf — nobody here can tell you what dose to be on and the ones who try get corrected, ymmv 20:14
- maintenance_mo — stepping back down on purpose is a completely reasonable move and this channel should say so more often 20:49
- maintenance_mo — if it "stopped working after four days" that is almost never pharmacokinetics 21:09
- slow.taper — if the current dose is still working, going up is spending headroom you might want later 22:30
- rezept_rolf — my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, thats one data point 23:00
if you are asking whether to go up, the fact you are asking usually means not yet
end of week thing
[edited]i went from 5 to 0.25 and honestly could not tell the difference in appetite
i have been at 1 for 22 months and honestly i have stopped wanting to move
split dosing has no trial behind it. people here do it and report on it, thats all, your mileage will differ
came down from a treatment dose to maintenance over about three months and it was uneventful
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hold
nobody here can tell you what dose to be on and the ones who try get corrected, ymmv
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too early imo
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
quick one the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
stepping back down on purpose is a completely reasonable move and this channel should say so more often
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
how long did you hold at 2.5 before you moved up
if it "stopped working after four days" that is almost never pharmacokinetics
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dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
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how much does the last dose still matter 6 days later
do you tell your prescriber you held or do you just hold
New independent result logged — SWB, lot KP-0925, purity 97.4% (Janoshik).
Inter-lab diff for lot A-2418: 98.1% vs 99.2%. Within expected range.
if the current dose is still working, going up is spending headroom you might want later
vial-a-2418-front.png
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follow up with a roughly seven day half-life you are near steady state after about five weeks at a dose
appetite returning at the end of the week is extremely common and is not the dose failing
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, thats one data point
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)