right so how much does the last dose still matter 4 days later
#dosing-titration 2025-05-07
Wednesday23 messages7 participantstimes are UTC
Highlights from this day
- eight_mm — dose day drift is mostly harmless with a weekly compound, but pick a day and defend it 19:16
- nausea_window — stepping back down on purpose is a completely reasonable move and this channel should say so more often 19:29
- nausea_window — sorry to jump in how do you decide between holding and stepping when both feel wrong 21:17
came down from a treatment dose to maintenance over about three months and it was uneventful
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update question: did anyone who held for 23 months regret it
whats the longest anyone has stayed on one dose
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
if you are asking whether to go up, the fact you are asking usually means not yet
stepping back down on purpose is a completely reasonable move and this channel should say so more often
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appetite returning at the end of the week is extremely common and is not the dose failing
update from 9 months ago: held at the same dose the whole time and still losing slowly
has anyone gone up and then straight back down and been glad they tried
with a roughly seven day half-life you are near steady state after about five weeks at a dose
coming down from 12 to 7.5, how bad is the appetite rebound
too early imo
is there a point where going up stops buying you anything
is week 33 too early to be thinking about the next step
end of week thing
holding is not failing. most people here who lasted two years held at least one dose for months
if it "stopped working after four days" that is almost never pharmacokinetics
i went from 5 to 1.7 and honestly could not tell the difference in appetite
small steps are better than big ones and the only reason people take big ones is impatience
sorry to jump in how do you decide between holding and stepping when both feel wrong
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if i hold at 5 indefinitely am i losing anything
quick one the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess