i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
#dosing-titration 2025-05-02
Friday43 messages10 participantstimes are UTC
Highlights from this day
- residual_solvent — if you are asking whether to go up, the fact you are asking usually means not yet, for what its worth 15:42
- apnoea_down_two — a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored 16:01
- residual_solvent — i escalate on symptoms. if the current dose is still doing something i stay on it, i think 16:14
- coa_or_cope — update question: did anyone who held for 2 months regret it 16:40
- two_ml_two — the ladder in the trials is a starting point, not a schedule you owe anyone dose day drift is mostly harmless with a weekly compound, but pick a day and defend it 17:24
sorry to jump in do you escalate on the calendar or on how you feel
if you are asking whether to go up, the fact you are asking usually means not yet, for what its worth
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)if the current dose is still working, going up is spending headroom you might want later
hold
my dose day has drifted 6 days later over 6 months, does it matter
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
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i escalate on symptoms. if the current dose is still doing something i stay on it, i think
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Testing queue: 9 submissions open, 19 awaiting dispatch.
update from 5 months ago: held at the same dose the whole time and still losing slowly
update question: did anyone who held for 2 months regret it
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
i hold for two months minimum before i decide a dose has stopped doing anything, thats just me
update from 12 months ago: held at the same dose the whole time and still losing slowly
too early imo
not advice
holding is not failing. most people here who lasted two years held at least one dose for months
came down from a treatment dose to maintenance over about three months and it was uneventful
the ladder in the trials is a starting point, not a schedule you owe anyone
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
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how do you tell a plateau from just being at your set point
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i have been at 7.5 for 6 months and honestly i have stopped wanting to move
does a missed week reset anything or do you just carry on
is there a trial anywhere that studied twice weekly, or is it all anecdote
end of week thing
thats anecdote
the honest answer is that most of us are running protocols nobody has ever studied
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coming down from 2.4 to 1, how bad is the appetite rebound
if it "stopped working after four days" that is almost never pharmacokinetics
you do not have to escalate at all. that is a real option that gets forgotten
how long did you hold at 12 before you moved up
the people who do best here are almost always the ones going slowest
plateau versus set point is not answerable in under six months of data
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with a roughly seven day half-life you are near steady state after about five weeks at a dose
genuine question appetite returning at the end of the week is extremely common and is not the dose failing
my titration ladder took 20 months to climb and i would do it slower again
after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
nobody here can tell you what dose to be on and the ones who try get corrected
go slower
janoshik-b-0329.pdf
2 pages · 828 KB · not retained in the public archive
the trials escalated on a fixed schedule because a trial has to. you are not a trial, i have it written down somewhere
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
small steps are better than big ones and the only reason people take big ones is impatience
i would hold