a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
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#dosing-titration 2025-04-24
Thursday43 messages9 participantstimes are UTC
Highlights from this day
- swab_dry_first — a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored 22:24
- thirty_one_g — the ladder in the trials is a starting point, not a schedule you owe anyone 22:50
- thirty_one_g — the trials escalated on a fixed schedule because a trial has to. you are not a trial, ymmv 23:02
- thirty_one_g — i escalate on symptoms. if the current dose is still doing something i stay on it, ymmv 23:10
- slow.taper — i went from 5 to 2.4 and honestly could not tell the difference in appetite 23:44
stepping back down on purpose is a completely reasonable move and this channel should say so more often
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
how do you decide between holding and stepping when both feel wrong
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if i took it 3 days late do i shift the schedule or go back to the old day
if the current dose is still working, going up is spending headroom you might want later
i would hold
sorry to jump in plateau versus set point is not answerable in under six months of data, i have it written down somewhere
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whats your rule for when a side effect means hold rather than push
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thats anecdote
whats a sensible maintenance dose after a year at treatment dose
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
is there a point where going up stops buying you anything
came down, no regrets
the ladder in the trials is a starting point, not a schedule you owe anyone
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update on the earlier thing with a roughly seven day half-life you are near steady state after about five weeks at a dose
i drifted from sunday to wednesday over a year and only noticed when i checked the log
you do not have to escalate at all. that is a real option that gets forgotten
thats noise
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n of 1
update from 3 months ago: held at the same dose the whole time and still losing slowly
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
the trials escalated on a fixed schedule because a trial has to. you are not a trial, ymmv
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do you escalate on the calendar or on how you feel
if it "stopped working after four days" that is almost never pharmacokinetics
wk 1-4 0.25mg
wk 5-10 0.50mg (held 2 extra weeks)
wk 11-14 1.00mg
wk 15-26 1.70mg (held, long)
wk 27+ 2.40mghow long did you hold at 2 before you moved up
i escalate on symptoms. if the current dose is still doing something i stay on it, ymmv
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)👀8🧪9
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
half life is a week
the honest answer is that most of us are running protocols nobody has ever studied, take that with a pinch of salt
steady state is 5 weeks
held for months
right so i went up too fast and im paying for it, do i drop back or ride it out
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anyone tracked whether a smaller more frequent dose changed their side effects
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
how much does the last dose still matter 3 days later
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my dose day has drifted 2 days later over 23 months, does it matter
came down from a treatment dose to maintenance over about three months and it was uneventful
i have been at 0.25 for 17 months and honestly i have stopped wanting to move
what does the room think about jumping a rung to catch up
update from 26 months ago: held at the same dose the whole time and still losing slowly
appetite returning at the end of the week is extremely common and is not the dose failing
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i went from 5 to 2.4 and honestly could not tell the difference in appetite
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end of week thing
small steps are better than big ones and the only reason people take big ones is impatience