#dosing-titration 2025-04-05

Saturday51 messages12 participantstimes are UTC

Highlights from this day

typosquat_tay — dose day drift is mostly harmless with a weekly compound, but pick a day and defend it 22:16
VialBot — Reminder for alt_ast_ali: dose day is today. Set 9 days ago. 22:48
half_life_hal — i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat 23:34

protein_floor 22:08

thats noise

typosquat_tay 22:10

if i hold at 2.4 indefinitely am i losing anything

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coming down from 1.7 to 7.5, how bad is the appetite rebound

peptidemeter-summary-d-0718.pdf

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protein_floor 22:13

unrelated but whats the smallest step anyone has managed between doses

after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice, someone check my working

medutest-report-b-0114.pdf

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typosquat_tay 22:16

dose day drift is mostly harmless with a weekly compound, but pick a day and defend it

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22:17ferrous_ash pinned a message

typosquat_tay 22:19

has anyone gone up and then straight back down and been glad they tried

typosquat_tay coming down from 1.7 to 7.5, how bad is the appetite rebound

night_pin 22:20

i have been at 2.4 for 6 months and honestly i have stopped wanting to move

the trials escalated on a fixed schedule because a trial has to. you are not a trial

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n of 1

typosquat_tay if i hold at 2.4 indefinitely am i losing anything

night_pin 22:26

the honest answer is that most of us are running protocols nobody has ever studied, i think

how long did you hold at 10 before you moved up

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for the archive came down from a treatment dose to maintenance over about three months and it was uneventful

VialBotbot22:31

Inter-lab diff for lot D-0718: 98.1% vs 98.6%. Within expected range.

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tokyo_taper 22:32

half life is a week

typosquat_tay coming down from 1.7 to 7.5, how bad is the appetite rebound

tokyo_taper 22:34

holding is not failing. most people here who lasted two years held at least one dose for months

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end of week thing

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seven_five_sweet 22:37

is there a trial anywhere that studied twice weekly, or is it all anecdote

lot_number_lou 22:39

i went from 7.5 to 2.5 and honestly could not tell the difference in appetite, i could be wrong

seven_five_sweet 22:41

i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else

lot_number_lou 22:43

while im here the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess

typosquat_tay coming down from 1.7 to 7.5, how bad is the appetite rebound

seven_five_sweet 22:45

you do not have to escalate at all. that is a real option that gets forgotten

is week 21 too early to be thinking about the next step

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VialBotbot22:48

Reminder for alt_ast_ali: dose day is today. Set 9 days ago.

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night_pin the trials escalated on a fixed schedule because a trial has to. you are not a trial

alt_ast_ali 22:50

plateau versus set point is not answerable in under six months of data

i escalate on symptoms. if the current dose is still doing something i stay on it

a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored

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thats normal

while im here i drifted from sunday to wednesday over a year and only noticed when i checked the log

night_pin for the archive came down from a treatment dose to maintenance over about three months…

alt_ast_ali 22:59

coming back to this small steps are better than big ones and the only reason people take big ones is impatience

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for the archive appetite returning at the end of the week is extremely common and is not the dose failing

night_pin 23:04

update from 10 months ago: held at the same dose the whole time and still losing slowly

dexa_or_bia 23:07

for the archive stepping back down on purpose is a completely reasonable move and this channel should say so more often
i log dose, day, weight and one line about how the week felt. thats enough to make decisions on

if you are going up because the scale stalled for two weeks, wait. two weeks is noise

alt_ast_ali 23:13

if i took it 3 days late do i shift the schedule or go back to the old day

i would hold

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underfill_uma 23:16

two weeks is nothing

alt_ast_ali i escalate on symptoms. if the current dose is still doing something i stay on it

dexa_or_bia 23:18

if you are asking whether to go up, the fact you are asking usually means not yet

anyone tracked whether a smaller more frequent dose changed their side effects

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VialBotbot23:24

Recon calculator: 40mg in 2ml = 2.5mg/ml.

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dexa_or_bia 23:25

steady state is 5 weeks

half_life_hal 23:26

is it normal for appetite to come back at the end of the week

do you escalate on the calendar or on how you feel

dexa_or_bia steady state is 5 weeks

half_life_hal 23:34

i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat

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ok so if the current dose is still working, going up is spending headroom you might want later

warsaw_vial 23:40

go slower

Cited study

Effect of Continued Weekly Semaglutide vs Placebo on Weight Loss Maintenance (STEP 4)

JAMA · 2021

The withdrawal arm. This is the trial to read before you plan to stop.

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update on the earlier thing i log dose, day, weight and one line about how the week felt. thats enough to make decisions on

if it "stopped working after four days" that is almost never pharmacokinetics

wk 1-4    0.25mg
wk 5-10   0.50mg   (held 2 extra weeks)
wk 11-14  1.00mg
wk 15-26  1.70mg   (held, long)
wk 27+    2.40mg

half_life_hal 23:50

nobody here can tell you what dose to be on and the ones who try get corrected

night_pin 23:58

sorry to jump in how do you tell a plateau from just being at your set point