vialroom

#dosing-titration 2025-03-13

Thursday16 messages4 participantstimes are UTC
Highlights from this day
  • net_peptide — unrelated but do you escalate on the calendar or on how you feel 08:41
  • net_peptide — my titration ladder took 22 months to climb and i would do it slower again 08:42
  • hydrate_hana — stepping back down on purpose is a completely reasonable move and this channel should say so more often 08:48
  • peak_split — i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else with a roughly seven day half-life you are… 10:09
  • peak_split — a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored if you are asking whether to go up, the fact you are… 10:15
NP

unrelated but do you escalate on the calendar or on how you feel

😂8⚠️53

my titration ladder took 22 months to climb and i would do it slower again

🎉14🧪10

thats normal

half life is a week

Cited study
Semaglutide vs Liraglutide for Weight Loss in Adults with Overweight or Obesity (STEP 8)
JAMA · 2022
Weekly against daily, head to head.

do you count from injection day or from when you actually felt it

HH

stepping back down on purpose is a completely reasonable move and this channel should say so more often

👍11❤️10
NP

no trial for that

Cited study
Once-Weekly Semaglutide in Adults with Overweight or Obesity (STEP 1)
New England Journal of Medicine · 2021
68 weeks, semaglutide 2.4mg weekly against placebo, with lifestyle intervention in both arms.
HH

follow up i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat

update on the earlier thing i escalate on symptoms. if the current dose is still doing something i stay on it, thats just me

VI

my dose day has drifted 3 days later over 24 months, does it matter

PS

i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
with a roughly seven day half-life you are near steady state after about five weeks at a dose

PS

a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
if you are asking whether to go up, the fact you are asking usually means not yet

🧪14😂15
VI

if i hold at 2 indefinitely am i losing anything
i went from 12 to 15 and honestly could not tell the difference in appetite