coming back to this if it "stopped working after four days" that is almost never pharmacokinetics
#dosing-titration 2025-02-23
Sunday29 messages5 participantstimes are UTC
Highlights from this day
- week_zero — sorry to jump in i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else 13:29
- area_percent — coming back to this is there a trial anywhere that studied twice weekly, or is it all anecdote 13:33
- area_percent — after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice 14:37
- madrid_mg — ok so split dosing has no trial behind it. people here do it and report on it, thats all, happy to be corrected 14:57
how do you decide between holding and stepping when both feel wrong
i would hold
sorry to jump in i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
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n of 1
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coming back to this is there a trial anywhere that studied twice weekly, or is it all anecdote
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)the people who do best here are almost always the ones going slowest
while im here small steps are better than big ones and the only reason people take big ones is impatience
not advice
is there a point where going up stops buying you anything
do you tell your prescriber you held or do you just hold
no trial for that
too early imo
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after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice
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holding is not failing. most people here who lasted two years held at least one dose for months
what does the room think about jumping a rung to catch up
do you escalate on the calendar or on how you feel
ok so split dosing has no trial behind it. people here do it and report on it, thats all, happy to be corrected
hold
end of week thing
you do not have to escalate at all. that is a real option that gets forgotten
slightly off topic but how long did you hold at 1 before you moved up
sorry to jump in anyone here split their weekly into two and would they do it again
update from 1 months ago: held at the same dose the whole time and still losing slowly
thats noise
is week 26 too early to be thinking about the next step
half life is a week
if i took it 2 days late do i shift the schedule or go back to the old day
update on the earlier thing coming down from 12 to 2.5, how bad is the appetite rebound