vialroom

#dosing-titration 2025-01-19

Sunday13 messages4 participantstimes are UTC
Highlights from this day
  • cold_start_cy — has anyone gone up and then straight back down and been glad they tried 18:55
  • point_two_five — update on the earlier thing my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, n of 1 obviously holding is not failing.… 18:57
  • lipase_lore — is there a trial anywhere that studied twice weekly, or is it all anecdote 20:02
  • cold_start_cy — genuine question if you are asking whether to go up, the fact you are asking usually means not yet 21:07
CS

anyone tracked whether a smaller more frequent dose changed their side effects

CS

i went from 15 to 2.4 and honestly could not tell the difference in appetite
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else

dose day drift is mostly harmless with a weekly compound, but pick a day and defend it

has anyone gone up and then straight back down and been glad they tried

Cited study
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
New England Journal of Medicine · 2023
48 weeks, dose-ranging. A Phase 2 result is not a safety record.

after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice

PT

update on the earlier thing my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, n of 1 obviously
holding is not failing. most people here who lasted two years held at least one dose for months

LL

the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess

is there a trial anywhere that studied twice weekly, or is it all anecdote

📉14
PT

update from 8 months ago: held at the same dose the whole time and still losing slowly

CS

genuine question if you are asking whether to go up, the fact you are asking usually means not yet

🧪1👍4👀1