hold
#dosing-titration 2024-11-09
Saturday41 messages8 participantstimes are UTC
Highlights from this day
- pbs_pip — the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess 14:26
- ten_of_ten — my dose day has drifted 2 days later over 25 months, does it matter 14:29
- step_one_sian — the people who do best here are almost always the ones going slowest 15:51
- vienna_vial — is there a point where going up stops buying you anything 17:32
go slower
small steps are better than big ones and the only reason people take big ones is impatience
*Janoshik not the other one
thats noise
thats anecdote
no trial for that
sorry to jump in whats the smallest step anyone has managed between doses
[edited]the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
transit-times.csv
715 rows · not retained in the public archive
for the archive stepping back down on purpose is a completely reasonable move and this channel should say so more often
my dose day has drifted 2 days later over 25 months, does it matter
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ok so if it "stopped working after four days" that is almost never pharmacokinetics
right so is there a trial anywhere that studied twice weekly, or is it all anecdote
if you are asking whether to go up, the fact you are asking usually means not yet, we shall see
i went from 10 to 2 and honestly could not tell the difference in appetite
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step, take that with a pinch of salt
if the current dose is still working, going up is spending headroom you might want later
i would hold
i escalate on symptoms. if the current dose is still doing something i stay on it
the people who do best here are almost always the ones going slowest
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you do not have to escalate at all. that is a real option that gets forgotten
how do you decide between holding and stepping when both feel wrong
anyone here split their weekly into two and would they do it again
right so do you tell your prescriber you held or do you just hold
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how much does the last dose still matter 3 days later
came down from a treatment dose to maintenance over about three months and it was uneventful
with a roughly seven day half-life you are near steady state after about five weeks at a dose
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split dosing has no trial behind it. people here do it and report on it, thats all
how do you tell a plateau from just being at your set point
nobody here can tell you what dose to be on and the ones who try get corrected
is there a point where going up stops buying you anything
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do you escalate on the calendar or on how you feel
thats normal
half life is a week
[edited]holding is not failing. most people here who lasted two years held at least one dose for months
anyone tracked whether a smaller more frequent dose changed their side effects
i hold for two months minimum before i decide a dose has stopped doing anything
the ladder in the trials is a starting point, not a schedule you owe anyone
*PeptideMeter not the other one