whats your rule for when a side effect means hold rather than push
#dosing-titration 2024-10-22
Tuesday31 messages9 participantstimes are UTC
Highlights from this day
- meniscus_mel — anyone tracked whether a smaller more frequent dose changed their side effects 16:21
- slow.taper — the ladder in the trials is a starting point, not a schedule you owe anyone 17:29
- mg_per_ml — i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else 17:49
- week_three_wall — i hold for two months minimum before i decide a dose has stopped doing anything 19:11
- VialBot — Inter-lab diff for lot H-2814: 97.4% vs 98.1%. Within expected range. 19:29
how do you tell a plateau from just being at your set point
i went from 12 to 7.5 and honestly could not tell the difference in appetite
holding is not failing. most people here who lasted two years held at least one dose for months, i could be wrong
anyone tracked whether a smaller more frequent dose changed their side effects
📈9✅3🤝2
slightly off topic but i escalate on symptoms. if the current dose is still doing something i stay on it
hold
i would hold
😂13👀3🧪8
the ladder in the trials is a starting point, not a schedule you owe anyone
🔥2👀16🙏8
if i took it 8 days late do i shift the schedule or go back to the old day
thats anecdote
small steps are better than big ones and the only reason people take big ones is impatience
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
🧊7
end of week thing
if the current dose is still working, going up is spending headroom you might want later, ill dig out the number
the trials escalated on a fixed schedule because a trial has to. you are not a trial
the honest answer is that most of us are running protocols nobody has ever studied
the people who do best here are almost always the ones going slowest
genuine question do you count from injection day or from when you actually felt it
i went from 7.5 to 2.4 and honestly could not tell the difference in appetite
do you escalate on the calendar or on how you feel
i went from 0.5 to 1 and honestly could not tell the difference in appetite
quick one i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
half life is a week
i hold for two months minimum before i decide a dose has stopped doing anything
🤝8✅1🎉2
if you are going up because the scale stalled for two weeks, wait. two weeks is noise
my rule: if a side effect is still there at day five, i hold. if it clears by day three, i step
Inter-lab diff for lot H-2814: 97.4% vs 98.1%. Within expected range.
🧊13🧪1
thats noise
🎉5⚠️2
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
how much does the last dose still matter 7 days later
is it normal for appetite to come back at the end of the week
if it "stopped working after four days" that is almost never pharmacokinetics
stepping back down on purpose is a completely reasonable move and this channel should say so more often