update question: did anyone who held for 4 months regret it
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#dosing-titration 2024-09-19
Thursday23 messages8 participantstimes are UTC
Highlights from this day
- thirty_min_wait — how much does the last dose still matter 9 days later 09:06
- step_one_sian — i log dose, day, weight and one line about how the week felt. thats enough to make decisions on, i think 09:10
- step_one_sian — slightly off topic but i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat, thats one data point 09:12
- lot_number_lou — quick one is there any actual reason to escalate every 4 weeks other than the trial did it i went from 0.25 to 1.7 and honestly could not tell the difference in… 11:18
came down, no regrets
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not advice
how much does the last dose still matter 9 days later
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the people who do best here are almost always the ones going slowest
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i log dose, day, weight and one line about how the week felt. thats enough to make decisions on, i think
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what does the room think about jumping a rung to catch up
slightly off topic but i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat, thats one data point
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steady state is 5 weeks
no trial for that
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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is there a point where going up stops buying you anything
the trials escalated on a fixed schedule because a trial has to. you are not a trial, take that with a pinch of salt
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else
i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else, n of 1 obviously
with a roughly seven day half-life you are near steady state after about five weeks at a dose
thats noise
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*that should say weekly
nobody here can tell you what dose to be on and the ones who try get corrected
quick one is there any actual reason to escalate every 4 weeks other than the trial did it
i went from 0.25 to 1.7 and honestly could not tell the difference in appetite
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whats the smallest step anyone has managed between doses
Purity check: no report on file for lot G-0641. Nothing logged either way.
a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored
*week 4 not week 7
i went up too fast and im paying for it, do i drop back or ride it out