whats the longest anyone has stayed on one dose
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
*week 2 not week 5
the trials escalated on a fixed schedule because a trial has to. you are not a trial, ill dig out the number
with a roughly seven day half-life you are near steady state after about five weeks at a dose, from memory
do you tell your prescriber you held or do you just hold
if you are asking whether to go up, the fact you are asking usually means not yet
anyone tracked whether a smaller more frequent dose changed their side effects
does it matter what day you inject on
not pharmacologically. massively practically
pick the day so the worst 48 hours land where you can afford them
i went friday evening for two years so the rough saturday was mine and not my employers
when is the worst bit usually
for me day 1 to 2 after. for others day 3. it varies and you will know within two doses
the peak concentration for the weekly injectables is a day or two out, so day 1 to 2 is the common answer
and if my worst day lands on a monday
move it once, cleanly, and then never move it again
and move it later rather than earlier if you can. shortening the interval raises your average, lengthening it lowers it
oh so going early is a dose increase
a small one, repeatedly, which is how people end up above the dose they think theyre on
i drifted from sunday to thursday over about eight months and blamed the vial
the vial gets blamed for so much in this channel
how do you actually stop drifting
an alarm you cannot dismiss and a log you have to type into. thats it, theres no clever answer
and take it late rather than skipping. a day late is nothing on a weekly half-life
what about missing one completely
worked example, roughly, weekly half-life
on schedule, at steady state you sit around 2.0 "units"
of accumulated drug (see the doubling maths in #semaglutide)
skip one week entirely:
day 7 2.0 -> no dose
day 14 1.0
day 21 0.5 + next dose
so one skipped week costs you about half your level and
takes ~3 weeks to build back. that is why a skipped dose
often shows up as a hungry fortnight, not a hungry day.
that explains the fortnight i had in may
and thats also why people who dose fortnightly on purpose are running a very different curve to a weekly one
very different. same weekly average is not the same peak to trough, and appetite tracks trough more than average
brb
is fortnightly a thing people do
for cost mostly, and for maintenance sometimes. its in the maintenance conversation further down
dose reminder for @luerlok: due today 19:00. current interval streak 11 weeks on schedule (personal best).
eleven weeks and the bot is prouder of me than my family
back. and the streak counter genuinely fixed my drift, which is embarrassing but true
gamification beats willpower every time
the move it later not earlier rule — does that hold when youre coming down a dose too
different question and yes, mostly. stretching the interval is the gentlest way to reduce exposure without changing what you draw
thats basically the whole taper conversation and it starts below