i log dose, day, weight and one line about how the week felt. thats enough to make decisions on
[edited]#dosing-titration 2024-07-13
Saturday25 messages6 participantstimes are UTC
Highlights from this day
- taper_tess — if you are asking whether to go up, the fact you are asking usually means not yet, n of 1 obviously 18:50
- taper_tess — the ladder in the trials is a starting point, not a schedule you owe anyone 19:05
- taper_tess — is it normal for appetite to come back at the end of the week 19:11
- rotate_the_site — slightly off topic but i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat 19:53
- ten_of_ten — dose day drift is mostly harmless with a weekly compound, but pick a day and defend it 20:09
half life is a week
[edited]thats anecdote
if you are asking whether to go up, the fact you are asking usually means not yet, n of 1 obviously
👀16🤝12📉1
the people who do best here are almost always the ones going slowest, from memory
the ladder in the trials is a starting point, not a schedule you owe anyone
🧪12👀1📉2
hold
🧊5🤝11✅18
is it normal for appetite to come back at the end of the week
👀6🧊5✅11
go slower
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)how do you tell a plateau from just being at your set point
update on the earlier thing i escalate on symptoms. if the current dose is still doing something i stay on it
😂1🔥8
nobody here can tell you what dose to be on and the ones who try get corrected
held for months
📉8
pick a day and stick to it
💀3📈1
slightly off topic but i jumped a rung once to catch up after a supply gap and it was a bad week. would not repeat
🧪1📉14🙏3
n of 1
if it "stopped working after four days" that is almost never pharmacokinetics
dose day drift is mostly harmless with a weekly compound, but pick a day and defend it
📈15💀1👍1
split dosing has no trial behind it. people here do it and report on it, thats all
i drifted from sunday to wednesday over a year and only noticed when i checked the log
plateau versus set point is not answerable in under six months of data
i hold for two months minimum before i decide a dose has stopped doing anything, for what its worth
came down from a treatment dose to maintenance over about three months and it was uneventful
end of week thing
too early imo