#dosing-titration 2024-05-21

Tuesday23 messages5 participantstimes are UTC

Highlights from this day

VialBot — Assay note: SWB lot B-0114 reported at 99.2% of label content. 19:14
noct.titrate — stepping back down on purpose is a completely reasonable move and this channel should say so more often 19:47
night_pin — my titration ladder took 11 months to climb and i would do it slower again 21:07

has anyone gone up and then straight back down and been glad they tried

the honest answer is that most of us are running protocols nobody has ever studied

Digest for the week of 2024-01-01 has been published.

Assay note: SWB lot B-0114 reported at 99.2% of label content.

plateau versus set point is not answerable in under six months of data, i have it written down somewhere

the trials escalated on a fixed schedule because a trial has to. you are not a trial, i have it written down somewhere

i went to the top of the ladder, felt no better than two rungs down, and came back. that is data for me and nobody else

i went from 7.5 to 15 and honestly could not tell the difference in appetite

came down, no regrets

📉1🎉16🔥1

if you are going up because the scale stalled for two weeks, wait. two weeks is noise

held for months

✅4

update from 5 months ago: held at the same dose the whole time and still losing slowly

stepping back down on purpose is a completely reasonable move and this channel should say so more often

🧊3📈3

steady state is 5 weeks

[edited]

dose day drift is mostly harmless with a weekly compound, but pick a day and defend it

n of 1

after a gap of more than about three weeks i restart one rung lower. thats my own rule, not advice

the ladder in the trials is a starting point, not a schedule you owe anyone

is it normal for appetite to come back at the end of the week

✅2

my titration ladder took 11 months to climb and i would do it slower again

anyone here split their weekly into two and would they do it again

i drifted from sunday to wednesday over a year and only noticed when i checked the log

i hold for two months minimum before i decide a dose has stopped doing anything