holding is not failing. most people here who lasted two years held at least one dose for months
#dosing-titration 2024-04-27
Saturday26 messages6 participantstimes are UTC
Highlights from this day
- noct.titrate — split dosing has no trial behind it. people here do it and report on it, thats all 08:10
- slow.taper — i went from 1 to 10 and honestly could not tell the difference in appetite 09:52
- noct.titrate — the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess 10:18
- lean_mass_lex — if it "stopped working after four days" that is almost never pharmacokinetics with a roughly seven day half-life you are near steady state after about five weeks at a… 11:10
is it normal for appetite to come back at the end of the week
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anyone tracked whether a smaller more frequent dose changed their side effects
end of week thing
my dose day has drifted 3 days later over 23 months, does it matter
the people who do best here are almost always the ones going slowest
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thats noise
held for months
came down, no regrets
hold
split dosing has no trial behind it. people here do it and report on it, thats all
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update from 24 months ago: held at the same dose the whole time and still losing slowly
i went from 1 to 10 and honestly could not tell the difference in appetite
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if you are asking whether to go up, the fact you are asking usually means not yet
whats the longest anyone has stayed on one dose
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
slightly off topic but i escalate on symptoms. if the current dose is still doing something i stay on it, someone check my working
[edited]follow up a missed week does not reset you, but going straight back to the top dose after a gap is how people get floored, n of 1 obviously
the argument for splitting is a flatter curve. the argument against is you have doubled your injections for a guess
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is there any actual reason to escalate every 4 weeks other than the trial did it
i drifted from sunday to wednesday over a year and only noticed when i checked the log
how do you tell a plateau from just being at your set point
thats normal
pick a day and stick to it
is there a trial anywhere that studied twice weekly, or is it all anecdote
steady state is 5 weeks
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i would hold
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if it "stopped working after four days" that is almost never pharmacokinetics
with a roughly seven day half-life you are near steady state after about five weeks at a dose
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