REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work, n of 1 obviously
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#cagrilintide 2026-06-05
Friday50 messages10 participantstimes are UTC
Highlights from this day
- swirl_not_shake — REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work, n of 1 obviously 16:03
- vialkeeper — its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake, happy to be corrected 16:17
- cagri_curious — stopped for 25 months and the fullness went within a fortnight of the last dose 16:46
- cass_cagri — the reason nausea reads differently is timing, mine arrived on the second day rather than the first 18:44
how many weeks before you noticed anything on monotherapy
is there a reason people titrate this over more weeks than the others
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its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake, happy to be corrected
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whats the recon people use, 40 in 0.5ml
stopped for 18 months and the fullness went within a fortnight of the last dose
dropped the GLP-1 and stayed on this alone for 1 months, appetite held but weight barely moved
anyone holding at 15 for a while before stepping
combination GI was worse than either alone for me, which is not what i had read anywhere
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is the nausea profile genuinely different or am i imagining it
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it, someone check my working
[edited]stopped for 25 months and the fullness went within a fortnight of the last dose
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back after 17 months, is monotherapy still a minority thing here
is the slower titration because of nausea or something else
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*Medutest not the other one
noticed something around week 22 on monotherapy, well after i had given up expecting to
i was sceptical about monotherapy and after 15 months im still sceptical, just less so
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lost 37lb over 2 months on the combination and i genuinely cannot apportion it
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dosing them on different days made no difference i could detect
monotherapy was underwhelming for me and i say that as someone who wanted it to work
[edited]did the combination change your GI compared to the GLP-1 alone
the fullness effect hasnt faded over 13 months, unlike my semaglutide appetite curve
i keep the two on separate days so if something goes wrong i have a chance of knowing which
monotherapy question, did appetite move for you without a GLP-1 alongside
did anyone add this to an existing semaglutide dose rather than starting both
the slower titration in here is community habit as much as anything, the trials had their own schedule
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
you cannot tell which of the two is doing what in a combination and i stopped pretending i could
is the weekly schedule the same here
held mine a while
[edited]slower than the others
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
different not less
how do people separate which of the two is doing what in a combination
the reason nausea reads differently is timing, mine arrived on the second day rather than the first
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cagri_curiousnoticed something around week 22 on monotherapy, well after i had given up expecting to
how slow are people titrating this compared to semaglutide
changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing
fullness rather than nausea
does amylin do something about fullness that the GLP-1 doesnt
is the combination just the two dosed together or a single formulation
the fullness thing is the part people describe differently, food stops being interesting rather than repellent
amylin analogue, so its not a GLP-1 at all right
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has REDEFINE reported or are people quoting earlier work
20 in 2ml gives 4mg/ml which is what i use, purely because the units come out round
titrating dead slow
the nausea felt different rather than less, more fullness and less of the queasy wave, from memory
i titrated over twice as many weeks as i did on semaglutide and that was right for me
is anyone running this on its own or is it all CagriSema in here
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weekly for me, same day every week, no reason beyond habit
cant separate them
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