anyone holding at 10 for a while before stepping
#cagrilintide 2026-06-02
Tuesday54 messages10 participantstimes are UTC
Highlights from this day
- HPLC_Hank — did anyone find monotherapy underwhelming 06:53
- lead_time_lars — monotherapy was underwhelming for me and i say that as someone who wanted it to work 07:06
- VialBot — Assay note: SWB lot H-2814 reported at 99.2% of label content. 07:44
- two_eight_c — has REDEFINE reported or are people quoting earlier work 09:58
did anyone find monotherapy underwhelming
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REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
the fullness effect hasnt faded over 4 months, unlike my semaglutide appetite curve, ymmv
monotherapy was underwhelming for me and i say that as someone who wanted it to work
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is the combination just the two dosed together or a single formulation
i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
the nausea felt different rather than less, more fullness and less of the queasy wave, n of 1 obviously
cant separate them
Assay note: SWB lot H-2814 reported at 99.2% of label content.
amylin not glp-1
for the archive i titrated over twice as many weeks as i did on semaglutide and that was right for me, from memory
$240 for a 10 vial and it lasts me longer than the GLP-1 does at my doses
cagrisema thats it
anyone stopped the GLP-1 and kept only this
i was sceptical about monotherapy and after 25 months im still sceptical, just less so
two Medutest results on the same QSC lot came back 99 and 96.8, closer than i expected
*Janoshik not the other one
the reason nausea reads differently is timing, mine arrived on the second day rather than the first
whats REDEFINE testing exactly
fullness rather than nausea
does amylin do something about fullness that the GLP-1 doesnt
changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing
is there a reason people titrate this over more weeks than the others
does the fullness effect fade the way appetite suppression does
has REDEFINE reported or are people quoting earlier work
weekly for me, same day every week, no reason beyond habit
while im here is the nausea profile genuinely different or am i imagining it
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did anyone add this to an existing semaglutide dose rather than starting both
did the combination change your GI compared to the GLP-1 alone
vial-kp-0925-front.png
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right so how do people separate which of the two is doing what in a combination
*Janoshik not the other one
is the slower titration because of nausea or something else
back after 16 months, is monotherapy still a minority thing here
quick one lost 37lb over 21 months on the combination and i genuinely cannot apportion it
right so noticed something around week 2 on monotherapy, well after i had given up expecting to
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
held at 15 for 5 months on monotherapy before i touched it again
update on the earlier thing monotherapy question, did appetite move for you without a GLP-1 alongside
[edited]*Medutest not the other one
REDEFINE is the trial
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
went slower because the first step gave me two rough days and i took that as information
anyone dosing this on a different day to their semaglutide
whats the recon people use, 20 in 2.5ml
is the weekly schedule the same here
titrating dead slow
different not less
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combination GI was worse than either alone for me, which is not what i had read anywhere
monotherapy did work for me, just slower and smaller than i expected
Testing queue: 9 submissions open, 84 awaiting dispatch.
nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
slower than the others
thats the phase 3 one
update on the earlier thing is 2.4 the number for this too or am i confusing compounds