combination GI was worse than either alone for me, which is not what i had read anywhere
#cagrilintide 2026-05-16
Saturday47 messages9 participantstimes are UTC
Highlights from this day
- provincial_pat — weekly for me, same day every week, no reason beyond habit 11:12
- rezept_rolf — the reason nausea reads differently is timing, mine arrived on the second day rather than the first 11:42
- provincial_pat — held at 2.5 for 3 months on monotherapy before i touched it again 12:07
- rezept_rolf — while im here you cannot tell which of the two is doing what in a combination and i stopped pretending i could 13:08
- lower_frequency — does the fullness effect fade the way appetite suppression does 13:10
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it, i have it written down somewhere
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
how many weeks before you noticed anything on monotherapy
i said earlier this year that monotherapy did nothing for me, and at a higher dose it did something
monotherapy did work for me, just slower and smaller than i expected
two PeptideMeter results on the same HJ lot came back 99.4 and 96.8, closer than i expected
the slower titration in here is community habit as much as anything, the trials had their own schedule
weekly for me, same day every week, no reason beyond habit
while im here monotherapy question, did appetite move for you without a GLP-1 alongside
i was sceptical about monotherapy and after 21 months im still sceptical, just less so
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the fullness effect hasnt faded over 17 months, unlike my semaglutide appetite curve
the fullness thing is the part people describe differently, food stops being interesting rather than repellent
did the combination change your GI compared to the GLP-1 alone
held mine a while
the reason nausea reads differently is timing, mine arrived on the second day rather than the first
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dropped the GLP-1 and stayed on this alone for 23 months, appetite held but weight barely moved
anyone dosing this on a different day to their semaglutide
held at 2.5 for 3 months on monotherapy before i touched it again
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the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
its an amylin analogue, different receptor family, so treating it as another GLP-1 is the first mistake
combination for me
unrelated but amylin is about slowed gastric emptying and satiety signalling, thats the short version and im no pharmacologist
*Janoshik not the other one
while im here dosing them on different days made no difference i could detect
while im here nobody should copy my schedule, im describing it because people asked what a slow ramp looks like
appetite_backcombination GI was worse than either alone for me, which is not what i had read anywhere
anyone stopped the GLP-1 and kept only this
while im here you cannot tell which of the two is doing what in a combination and i stopped pretending i could
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does the fullness effect fade the way appetite suppression does
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fullness rather than nausea
stopped for 19 months and the fullness went within a fortnight of the last dose
two Medutest results on the same KP lot came back 99 and 97.4, closer than i expected
how slow are people titrating this compared to semaglutide
different not less
$185 for a 2 vial and it lasts me longer than the GLP-1 does at my doses
separate days
added it to an existing cagrilintide dose rather than starting both, which made attribution possible, still working it out
went slower because the first step gave me two rough days and i took that as information
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
changed my mind on this, i started thinking amylin was the interesting bit and now i think its the pairing, i have it written down somewhere
the slower titration in here is community habit as much as anything, the trials had their own schedule
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amylin analogue, so its not a GLP-1 at all right
slower than the others
15 in 2.5ml gives 8mg/ml which is what i use, purely because the units come out round
anyone holding at 1.7 for a while before stepping
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
did anyone find monotherapy underwhelming
On this day 2 years ago this channel logged 61 messages.
cant separate them