the reason nausea reads differently is timing, mine arrived on the second day rather than the first
#cagrilintide 2026-04-22
Wednesday45 messages9 participantstimes are UTC
Highlights from this day
- loam_logs — CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it noticed something around week 20 on monotherapy, well after i had given up… 20:19
- power_through_no — monotherapy was underwhelming for me and i say that as someone who wanted it to work 21:00
- panel_before_after — you cannot tell which of the two is doing what in a combination and i stopped pretending i could 22:08
sorry to jump in the fullness effect hasnt faded over 5 months, unlike my semaglutide appetite curve
is the slower titration because of nausea or something else
the fullness effect hasnt faded over 13 months, unlike my semaglutide appetite curve
different not less
does amylin do something about fullness that the GLP-1 doesnt
REDEFINE is the phase 3 programme, most of what gets quoted casually in here is earlier work
the combination is the thing with trial data behind it, monotherapy in here is mostly us guessing
update on the earlier thing did anyone add this to an existing cagrilintide dose rather than starting both
unrelated but anyone got two VendorInvestigate results on the same WWB lot for this
added it to an existing cagrilintide dose rather than starting both, which made attribution possible
CagriSema is cagrilintide with semaglutide and REDEFINE is the trial programme around it
noticed something around week 20 on monotherapy, well after i had given up expecting to
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noticed something around week 28 on monotherapy, well after i had given up expecting to
held mine a while
whats the recon people use, 5 in 0.5ml
does the fullness effect fade the way appetite suppression does
held at 0.25 for 5 months on monotherapy before i touched it again
stopped for 25 months and the fullness went within a fortnight of the last dose
anyone dosing this on a different day to their semaglutide
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genuine question the fullness thing is the part people describe differently, food stops being interesting rather than repellent
monotherapy was underwhelming for me and i say that as someone who wanted it to work
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did anyone find monotherapy underwhelming
if youre used to GLP-1 titration steps this feels absurdly cautious and i still do it that way
is the combination just the two dosed together or a single formulation
monotherapy here
combination GI was worse than either alone for me, which is not what i had read anywhere
cant separate them
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underwhelming honestly
the numbers everyone quotes come from the combination, so comparing them to monotherapy logs is unfair
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REDEFINE is the trial
combination for me
did the nausea feel different to you or just less
weekly for me, same day every week, no reason beyond habit
[edited]anyone stopped the GLP-1 and kept only this
anyone holding at 12 for a while before stepping
cagrisema thats it
*that should say weekly
titrating dead slow
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you cannot tell which of the two is doing what in a combination and i stopped pretending i could
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lost 98lb over 4 months on the combination and i genuinely cannot apportion it
*Medutest not the other one
unrelated but monotherapy did work for me, just slower and smaller than i expected, for what its worth
how many weeks before you noticed anything on monotherapy
[edited]two VendorInvestigate results on the same MKM lot came back 99.4 and 97.4, closer than i expected